Pancreas and Gallbladder Pathology -Guo

Question 1

What are the 2 types of acute pancreatitis?

Answer 1

edematous and hemorrhagic necrosis (necrotizing)

Question 2

What are the 2 most common causes of acute pancreatitis?

Answer 2

gallstones and alcohol

Question 3

Is a biopsy needed for acute pancreatitis?

Answer 3

NO

mostly based on physical signs and symptoms and serum levels of enzymes (elevated lipase and amylase)

Question 4

How does fat necrosis develop from acute pancreatitis? What other lab abnormality does this lead to?

Answer 4

lipase attacks fats releasing FFA that combine with Ca2+ to form salts and deposits

also causes hypocalcemia

Question 5

What is a pseudocyst?

Answer 5

collections of pancreatic juice, usually rich in digestive enzymes, that are enclosed by a non-epithelialized wall composed of fibrous and granulation tissue

Question 6

What are the differences between acute and chronic pancreatitis (pathophysiology, complications)?

Answer 6

Acute: Autodigestion, edema, hemorrhagic fat
necrosis, saponification, hypocalcemia,
pseudocysts.

Chronic: Irreversible parenchymal damage,
progressive parenchymal fibrosis,
chronic malabsorption,
diabetes mellitus.

Question 7

What is removed in a Whipple procedure?

Answer 7

Pancreatic duct and the duodenum (for ductal adenocarcinoma)

Question 8

Where do most pancreatic cancers originate?

Answer 8

in the exocrine pancreas (95%)