Liver Pathology -Guo Flashcards
True or False: Zone 3 is next to the central vein and is least supplied by oxygen and at risk for hypotension and congestion.
True
When can Hepatitis D infect?
with Hepatitis B
How is Hepatitis C graded?
biopsy!
-G0–> G3
need to determine inflammation and necrosis
-S1–> 3 for fibrosis (S2=portal septa, S3=bridging fibrosis)
How is autoimmune hepatitis diagnosed?
- diagnosis of exclusion
- 70% women, 20-45 yo
What is the most common cause of cirrhosis in the Western world?
Alcohol
What histologic finding will be seen in Chronic Hepatitis B?
Ground glass hepatocytes
What histologic finding will be seen in Chronic Hepatitis C?
Portal tract lymphoid aggregates
What histologic finding will be seen in Autoimmune hepatitis?
interface hepatitis, plasma cell infiltrates, autoantibodies
What histologic finding will be seen in acute hepatitis?
inflammatory infiltrates and councilman bodies
What are the risk factors for hepatocellular carcinoma?
- Chronic Hep B (»>) or Hep C virus
- cirrhosis
- smoking
- higher risk in blacks
What populations of people get hepatocellular carcinoma?
- 60yo with cirrhosis
- 20-40 yo without cirrhosis
What is the #3 most frequent cause of cancer related death?
Hepatocellular carcinoma
What is the typical presentation of fibrolamellar HCC?
- male=female
- young age (25)
- normal AFP
- good prognosis
What is the most common autosomal recessive genetic disorder?
Hemochromatosis –> causes the abnormal accumulation of iron in parenchymal organs –> organ toxicity
-secondary can be caused by disorders of erythropoiesis and treatment of diseases with blood transfusions
What is the most common genetic liver disorder in children and infants?
Alpha-1 antitrypsin deficiency
