Pancreas Flashcards
Name the pancreatic pathologies represented
A - MD IPMN
B - BD IPMN
C - Mixed
What characteristics of IPMN are worrisome vs high risk. What do we do after identifying one of these criteria?
Name five non BRCA syndromes associated with breast cancer and their other cancers
Li-Fraumeni syndrome (p53 mutation) is associated with breast cancer and also associated with sarcomas, brain tumors, leukemia, and adrenocortical malignancies.
Cowden syndrome (PTEN mutation) is associated with breast cancer and also associated with mucocutaneous lesions, thyroid cancer, and endometrial cancer.
Ataxia telangiectasia (ATM mutation) can be associated with breast cancer and also with cerebellar and neuromotor deterioration, lymphoma, and leukemia.
Muir-Torre syndrome (mutations in MLH1 and MSH2) is most commonly associated with multiple skin tumors as well as benign and malignant tumors of the GI and genitourinary tracts. Occasionally, these patients can also have breast cancer.
Beckwith-Wiedemann syndrome is not associated with an increased risk of breast cancer.
Go to reconstruction for bilateral mastectomy with adjuvant rads
tissue expander followed by lat dorsi flap
First step for milk fistula in breast feeding patient
keep breast feeding then surgery if no improvement
Lifetime risk of patients with LCIS
20%
Risk reductions for BRCA: mastectomy v oopherectomy
90 v 50
Treatment for ER pos DCIS
lump plus rads and hormone therapy
5 screening recommendations for BRCA1
Annual MRI starting at age 25
Annual mammogram starting at age 30
Annual ovarian cancer screening (including transvaginal ovarian ultrasounds, cancer antigen-125 [CA-125], pelvic examinations) starting at age 30
Biannual clinical breast examination beginning at age 25
Monthly self-breast examination starting at age 18
Which BRCA has more of an association with Prostate and male breast cancer
2
