Palliative care Flashcards
Chemoreceptor trigger zone situated where
postrema on the floor of 4th ventricle
Vomiting centre situated where
Close to CTZ, in medulla
With regards to BBB where are CTZ/ vomiting centre are
Inside BBB ; VOMITING CENTRE
Outside BBB: CTZ
Vomiting centre role
Collection of motor nuclei
Coordinates emetic process
Antiemetics for peripheral cause of nausea/vomitting
prokinetics
Prokinetics eg
Domperidone
Metoclopramide
Antiemetics for CTZ centrally caused nausea and vomiting
D2 antagonist
D2 antagonist eg
Haloperidol
Antiemetics for other centrally caused nause and vomiting
H1 antagonist
H1 antagonist eg
cyclizine
Levomepromazine
Broad spectrum antiemetic
antagnoist at 5HT2, H1, A1
Granisetron
anti emetic 2nd line
5HT3 antagonist
Aprepitant
antiemetic 2nd line
neurokinin receptor antagonist
Nabilone
2nd line antiemetic
cannabinoid (specialist use only)
Laxative classes
Softner
Stimulant
Osmotic
Bulk forming
Softner eg
docusate
Stimulant eg
Senna
Bisacodyl
Osmotic eg
Movicol
Laxido
Lactulose