Oncology Flashcards
Adjuvent rx
after radical therapy
reduces risk of recurrence
Neo-adjuvant
given before primary therapy
reduces morbidity and recurrence
Drugs for ER +ive tumours
Premenupause: tamoxifen
Postmenupause: aromatase inhibitor (goserelin)
Immunotherapy adv
improves immune response to cancer
Immunotherapy disadv
get autoimmune conditions everywhere
Lymphoedema (post mastectomy) rx
Compression garnment
Sx most likely to be a sign of cancer recurrance
Groin pain
Pleural disease
Most important blood test to identify mets breast disease
calcium level (hypercalcaemia in cancer)
What SE of morphine will make you change the dose of morphine
Renal failure
Muscle twitching
What type of surgery better for non small cell lung cancer
Lobectomy better than wedge
better survival
Hormone therapy for prostate cancer
Start bicalutamide
7 days later give goserelin (injection in abdo)
Repeat every 3 months
Check PSA
Bicalutamide
HRT (goserelin) makes you worse before better
Bicalutamide acts more quickly to reduce testosterone levels
Stopping you from getting worse at the beginning
Tamoxifen SEs
Menupause
Endometrial Cancer
DVT/PE
Aromitase inhibitors SE
Osteoprosis/fracture
Referral to coroner officer
Cause of death not known
Not seen by doc last 14days
Had an accident (eg fall) within 1 yr, related to death
Industrial related disease
Death was violent or circumstances suspicious
Evidence of neglect
Suicide
Death during or after an operation
Aromatase inhibitors eg
letrozole
anastrozole
Sources of oestrogen
Breast and peripheral tissues
Ovaries
Adrenal glands
HER2+ tissue rx
Herceptin (trastuzumab)
SEs of radiotherapy
Pulmonary/cardiac toxcity
Lymphoedema
Breast cancer mets
Brain
Lung
Liver
Bones
Gammaknife
for oligo-metastatic (brain mets) disease
high dose of radiation given
SVCO
superior vena cava obstruction
SVCO sx
Face/neck oedema
Upper chest venous dilatation
Pemberton’s sign
Pemberton’s sign
raise hands above head
congestion and cyanosis of face
due to narrowing of thracic inlet
