Palliative Care Flashcards
Rx for N&V due to GI tract damage and how does it work
Mediated through 5-HT3 receptors and blocked by 5-HT3 antagonists
Ondensetron, Granisetron
Rx for N&V due to liver swelling/damage and how does it work
Mediated through dopamine receptors and blocked by dopamine antagonists
Domperidone, Meoclopramide, Haloperidol
Rx for N&V due to vestibular problems and raised ICP and how does it work
mediated through ACh and histamine receptors and blocked by anticholinergics
Cyclizine
How does cyclizine work
Histamine-1-receptor antagonist with anti muscarinic properties
How does cyclizine exert an effect
via the chemoreceptor trigger zone in the medulla oblongata
best anti emetic for N&V secondary to delayed gastric emptying
domperidone (increases peristalsis)
best anti emetic for refractory N&V
holperidol
what age group aren’t allowed pcm
< 3 months
conversion
oral morphine : sc morphine
2 : 1
conversion
oral morphine : iv morphine
2 : 1
conversion
oral morphine : oral oxycodone
2 : 1
conversion
oral morphine : sc oxycodone
4 : 1
conversion
oral morphine : iv diamorphine
3 : 1
conversion
oral oxycodone : sc oxycodone
2 : 1
criteria for brainstem death to be confirmed
needs 2 medical practitioners
no pupillary response to light
no eye movements
absent cough or gag reflex
no pain response
no blink response
irreversible cessation of circulatory and respiratory functions
