Pain.Sedation.Delirium

Question 1

Dose of ketamine in which psychomimetic (alteration in consciousness or perception) are essentially zero.

Answer 1

0.12 mg/kg/hr

Question 2

List the 4 centrally acting alpha 2 agonists which can be used for ICU sedation/withdrawal

Answer 2

1. Dexmedetomidine (Precedex)
2. Clonidine
3. Tizanidine (Zanaflex).
4. Guanfacine (Tenex)

Question 3

What can be done to counteract bradycardia in patient who really needs Precedex infusion?

Question 4

Tizanidine metabolism

Answer 4

Hepatic CYP1A2 system (fluoroquinolones may increase levels).