Named Studies Flashcards

1
Q

VIOLET Study (2020) (Vitamin D to Improve Outcomes by Leveraging Early Treatment)

A
  • randomized, double-blind, placebo-controlled, phase 3 trial of early vitamin D3 supplementation in critically ill, vitamin D–deficient patients who were at high risk for death
  • Early administration of high-dose enteral vitamin D3 did not provide an advantage over placebo with respect to 90-day mortality or other, nonfatal outcomes among critically ill, vitamin D–deficient patients.
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2
Q

ELAIN Study (2016) (Effect of Early vs Delayed Initiaion of Renal Replacement Therapy on Mortality)

A
  • Single-center randomized clinical trial of 231critically ill patients with AKI Kidney Disease: Improving Global Outcomes (KDIGO) stage 2(2 times baseline or urinary output <0.5 mL/kg/h for12 hours)
  • Early (within 8 hours of diagnosis of KDIGO stage 2; n = 112) or delayed (within 12 hours of stage 3 AKI or no initiation; n = 119) initiation of RRT
  • 90 day mortality Early group 39.3% vs Delayed group 54.7%
  • Length of hospital stay: 51 days vs 82 days
  • Median duration of mechanical ventilation: 125.5 hrs vs 181.0 hrs (P = 0.002)
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3
Q

STAART-AKI (2020)(STandard versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury trial)

A
  • Multinational, multi center randomized controlled trial
  • Early (KDIGO stage 2 or 3 AKI with initiation of RRT within 12 hours) compared to standard therapy
  • No difference in 90 day mortality
  • More patients requiring long term RRT in early group and more adverse events in early group.
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4
Q

VANISH (2016) (Early Vasopressin vs Norepinephrine on Kidney Failure in Patients with Septic Shock)

A
  • A factorial (2x2), randomized, double-blind clinical trial
  • Comparing vasopressin as a first line vasoactive medication compared to norepinephrine
  • No different in kidney-failure free days (primary outcome)
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5
Q

PICARD study (2002)(Project to Improve Care in Renal Disease)

A
  • Retrospective Cohort Study with Propensity Matched score
  • Diuretic use was more likely to be associated with death or nonrecovery of renal function (OR 1.68, 1.79)
  • Not a great study. Low numbers with differences in baseline characteristics. Multiple diuretics used. Retrospective. Data from 80s. Single region.
  • Contrast with Prospective observational study published in 2004 with more rigorous stats. Did not show statistically significant association between diuretics and mortality. But also did not show benefit.
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6
Q

SAFE (2004) (Saline vs Albumin Fluid Evaluation)

A
  • Prospective, multi center, randomized, double blind trial
  • Excluded cardiac surgery, liver transplant, and burn surgery
  • no difference in mortality at 28 days, ICU days, hospital stay, mechanical ventilation days, or days of RRT between 4% albumin vs 0.9% saline.
  • Maybe advantage to albumin in severe sepsis (mortality OR 0.87)
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7
Q

ALBIOS (2014) (Albumin Italian Outcome Sepsis Study)

A
  • Multi center, open - label, randomized trial
  • 20% albumin + crystalloid (targeting serum albumin 30 g/L) vs crystalloid alone
  • No difference in 28 day or 90 day survival
  • Post hoc analysis showed 90 day survival benefit of albumin in septic shock but detriment for patients with severe sepsis without shock.
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