Pain/Related Conditions Flashcards
Non-opioid analgesics: Acetaminophen
-reduces pain (analgesia) and fever (antipyretic) but does not provide anti-inflammatory effect, does not inhibit thromboxane (no effect on platelets)
–> peds dose: 10-15 mg/kq q 4-6H, infant sus: 160mg/5mL
Combos: Acetaminophen
+. hydrocodone (Norco, Vicodin, Lortab)
+ Oxycodone (Percocet, Endocet)
+ Codeine (Tylenol #2,3,4)
+ Tramadol (Ultracet)
+ Butalbital/Caffeine (Fioricet)
+ Diphenhydramine (Tylenol PM)
Acetaminophen Overdose*
MAX DOSE: 4000 mg/day and 325 mg/rx dosing unit
Antidose for APAP is N-acetylcysteine (oral or Acetadote IV)
–> restores intracellular glutathione
-available in both oral and IV formulation
The Rumack-Matthew nomogram uses the serum acetaminophen level and the time since ingestion to determine whether hepatotoxicity is likely & the need for NAC
NSAIDs and the Ductus Arteriosus *
before birth, the DA connects the pulmonary artery to the aorta, allowing oxygenated blood to flow to the baby, bypassing the immature lungs
**do NOT use NSAIDs in the 3rd trimester of pregnancy- can prematurely close the DA
–> IV NSAIDs (Indomethacin, Ibuprofen) can be used within 14 days after birth to close a patent DA
Non-selective NSAIDs
-Ibuprofen (advil, motrin): ped 5-10mg/kg/dose q6-8h
-Idomethacin (Indocin, Tivorbex): PDA closure, higher risk for CNS & GI toxicity
-Naproxen (Aleve): 200 mg Q8-12H [ + esomeprazole (Vimovo) for GI protection, + sumatriptan (Treximet) for migraine]
-Ketorolac (Toradol): indicated as a cont of IV or IM ketorolac, max combined duration = 5 days, SE: acute renal failure, liver failure
COX 2 selective NSAIDs
*inc risk of MI/stroke: avoid with CV risk
-Celecoxib (Celebrex): highest COX 2 selectivity, CI w/ sulfa allergy, SE: lower GI, renal complications,
-Diclofenac (voltaren): [ + misoprostal (Arthrotec) - replaces gut-protective prostaglandins to dc GI risk- avoid in females of childbearing potential)
-Meloxicam (mobic)
Salicylate NSAIDs: Aspirin
(Bufferin, Ecotrin- EC, Durlaza ER)
BBW: NSAID hypersensitivity, risk of Reye’s syndrome, severe skin reactions
–> if used ASA w/ ibuprofen, take ASA 1 hr before or 8 hrs after ibuprofen
[ non-acetylated salicylates: Magnesium salicylate (Doans) - for back pain ]
Opioid Boxed Warnings*
-addiction, abuse and misuse can lead to overdose and death
-respiratory depression, which can be fatal
-use of any opioid w/ benzos or other CNS depressants (including alcohol), can increase the risk of death
-Kadian, Embeda, Zohydro and Nucynta ER do not consume with alcohol
-accidental ingestion/exposure of even one dose in children = fatal
-crushing, dissolving, or chewing of the long acting products can cause the delivery of a potentially fatal dose
-life-threatening neonatal opioid withdrawal with prolonged use during pregnancy
Common Opioids: Codeine
–> C-II
-Codeine + APA (Tylenol #2,3,4) = C III –> used as antitussive (anti-cough) - codeine cough syrups are C V
BBW:
-ulta rapid metabolizers of codeine (CYP450 2D6 polymorphisms) = OD/death
-CI in children < 12 y/o
Common opioids: Fentanyl
(Duragesic, Sublimaze) - C-II
Patch: 12, 25, 50, 75, 100 mcg/h, change patch Q 3 days
-for chronic pain management only:
–> not for opioid naive patients
–> pts who have been taking morphine 60 mg daily or equiv for at least 7 days can be converted to a patch
-effects can be seen 8-16 hrs after application, some may need to be removed prior to MRI
-apply to hairless skin and press in place for 30 secs,
-dipose by flushing down the toilet
Common Opioids: Hydrocodone
C-II
–> Hydrocodone + APAP (Norco, Lorcet, Lortab, Vicodin) = IR
–> Hydrocodone ER (Zohydro, Hysingla ER, Vantrela ER)
BBW: CYP3A4 inhibitors = can cause cause fatal overdose
Common opioids: Hydromorphone
(Dilaudid) - C-II
**safety issues: POTENT; start low, convert carefully
–> satarting dose: 0.2-1 mg IV Q 2-3 hrs
-caution with 3A4 inhibitors, use lower doses initially
Common Opioids: Methadone
(Dolophine, Methadose) - C-II
-approved for heroin detox (used more for pain)
-should be prescribed by those who know the requirements for safe use
-variable 1/2 life: 15-55 hrs
-risk of QT prologation, can be aggravated if dosed incorrectly
-can decrease testosterone, reduce sexual function in men
-serotonergic
Common Opioids: Meperidine
(Demerol) C-II
-not for chronic pain: short acting, toxic metabolite, not for elderly
-renally cleared metabolite (normeperidine) that is lipophilic/ toxic if accumulated
SAFETY ISSUES: renal clearance, CNS toxicity –> seizures
Common Opioids: morphine
(MD Contin, Kadian) C-II
K: can open and sprinkle on apple sauce
Common opioids: Oxycodone
(Oxaydo, RoxyBond, Roxicodone) C-II
CR: Oxycontin
ER: Xtampa
+ APA = Endocet, Percocet
Safety issues: abuse/misuse, do not use with 3A4 inhibitors
Opioid dosing conversions *
Morphine:
–> IV: 10 mg
–> PO: 30 mg
Hydromorphone:
–> IV: 1.5
–> PO: 7.5
Oxycodone:
–> PO: 20 mg
Hydrocodone:
–> PO: 30 mg
Morphine-type allergy*
-the common drugs in the same chemical class that cross-react w/ each other have COD or MORPH in the name
-codeine
-hydrocodone
-oxycodone
-morphine
-hydromorphone
-oxymorphone
-bupenorphine
-heorin
opioid allergy symptoms: difficulty breathing, severe drop in BP, serious rash, swelling of face, lips, tongue, larynx
–> if true allergy options are: fentanyl, meperidine, methadone, tapentadol
Opioid induced constipation *
-stimulants (Senna, biscodyl) or osmotic (PEG) laxatives are the typical 1st line, with or w/o stool softner
-if those dont work, can use OIC’s : Methylnaltrexone (Relistor), Naloxegol (Movantik), Naldemedine (Symoroic), Lubiprostone
Centrally acting analgesics: Tramadol
(Ultram) C-IV, + APAP (Ultracet)
Warnings: seizure risk, serotonin syndrome, avoid with 2D6 inhibitors
SEs: dizziness, nausea, consitpation, loss of appetite, flushing, insomnia,
Centrally acting analgesics: Tapentadol
(Nucynta) C-II
-seizure risk
-serotonin syndrome risk
-dizziness, drowsiness, nausea but less GI side effects than opioids
Opioid overdose management*
-Narcan (nasal spray): onset of action is slower than injection, a single-use nasal spray is 4 mg admin in 1 nostril, repeat doses in alternating nostrils may be needed
-Naloxone (injection): generic formulation provided in multiple size vials, separate syringe will be needed, may need to repeat doses q 2-3 mins until emergency medical assistance arrives
Common adjuvants for pain management
A. Anti-epileptic drugs: Gabapentin (Neurontin), Pregabalin (Lyrica), Carbamazepine
B. Antispasmodics (muscle relaxants) w/ analgesic effects: Baclofen (Lioresal), Cyclobenzaprine (Fexmid), Tizanadine (Zanaflex)
C. Antispasmodics (muscle relaxants) that work via sedation: Carisoprodol (Soma), Methocarbamol (Robaxin)
Topical Adjuvants for pain control
-Lidocaine (Lidoderm) - up to 3 patches on body, can cut patches
-Capsaicin (Zostrix)
-Methyl salicylate (BenGay, IcyHot)
Common Migraine Triggers*
1: Hormonal changes in Women
-estrogen fluctuations
-use progestin-only contraceptives in migraines with aura
2: Foods: beer, red wine, aged cheese, chocolate, aspartame, MSG, salty foods, processed foods
3: Stress: major cause of migraine
4: Changes in wake-sleep pattern: too much or too little sleep, including jet lag
5: Changes in the Environment: barometric pressure or weather changes
Acute Migraine tx: triptans
-serotonin receptor type 1B and 1D agonists
-Rizatriptan (Maxalt-MLT) : 6 yrs+
-Sumatriptan (Imitrex) : may be repeated once after 2 hrs
-Zolmitriptan (Zomig ZMT) 12 y/o+
-Sumatriptan/naproxen (Treximet): abortive, must be in original container (> 12 y/o+)
CI: cerebrovascular disease, cardiovascular disease, (stroke, TIA, MI, uncontrolled HTN)
Warnings: inc BP, serotonin syndrome
SEs: paresthesias (numb/tingling), triptan sensations (neck and chest pressure)
–> Frovatriptan & naratriptan: longer duration of action, slower onset of action
Acute migraine tx: Triptan Formulations*
A. Tablets: all
B. ODT: Rizatriptan (Maxalt), Zolmitriptan (Zomig)
C. Nasal Spray: Sumatriptan –> no priming, i spray in ONE nostril (may repeat once after 2 hrs)
D. Nasal Powder: Sumatriptan –> 1 spray into EACH nostril (repeat once after 2 hrs)
E. SC injection: sumatriptan (may repeat once after 1 hr)
Acute migraine tx: Ergotamine drugs
-Dihydroegotamine (DHE 45, Migranal) : IM/SC/IV, nasal spray - must prime 4 pumps
-Ergotamine + Caffeine (Cafergot): tab, supp
–> non selective serotonin agents, caise cerebral vasoconstriction, generally considered in pts who do not respond to triptans
BBW: CI with potent CYP3A4 inhibitors (GPACMAN)
CI: uncontrolled HTN, ischemic heart disease, angina, MI, peripheral vascular disease, pregnancy, use within 24 hrs of triptans or other ergotamine-type drugs
Warnings: cardiovascular effects, cerebrovascular events, intense vasoconstriction, DDIs
Acute migraine tx: CGRP antagonists
-helps to treat or prevent migraines from occurring (dec inflammation + vasodilation)
–> Rimegepant (Nurtec ODT) - approved for both treatment and ppx
–> Ubrogepant (Ubrelvy): can take second dose if first one does not offer relief
Serotonin Receptor Agonist: Lasmiditan
(Reyvow)- schedule V
-NO vasoconstriction, NO contraindications,
SE: CNS depression
-strong inhibitor of P-gp
Prophylactic tx of migraines: Beta Blockers
-Propranolol (Inderal)
-Metoprolol t (Lopressor)
-Metoprolol S (Toprol XL)
-Timolol
Warnings: caused with asthma COPD
SE: bradycardai, fatigue, hypotension, impotence
Prophylactic tx of migraines: Anti epileptics
-Divalproex (Depakote), Valproic acid
–> BBW: fetal harm, hepatic failure, pancreatitis
–> SEs: weight gain, thrombocytopenia, inc ammonia, alopecia, N/V,
-Topiramate (Topamax)
–> Warnings: fetal harm, metabolic acidosis, nephrolithiasis, inc ammonia, open angle glaucoma, oligohidrosis (dec sweating)
–> SE: weight loss, somnolence, cognitive impairment & reduced efficacy of oral contraveptives
Prophylactic CGRP Antagonist
PO:
-Atogepent (Qulipta)
-Rimegapant (Nurtec)
Parenteral:
-Eptinezumab (Vyept) IV Q 3 mon
-Ernumab (Aimovig) SC monthly
-Fremanezumab (Ajovy) SC monthly or q 3 mon
-Galcancezumab (Emgality) Sc monthly
Drugs that can increase uric acid*
-aspirin, low doses
-calcineurin inhibitors (tacrolimus, cyclosporine)
-Diuretics (loop and thiazides)
-Niacin
-Pyrazinamide (tb drug)
-select chemo therapies (tumor lysis syindrome causing) and pancreatic enzymes
Acute Gout tx: NSAIDs
-Indomethacin (Indocin): 50 mg TID until pain is tolerable - then taper down
-Naproxen (aleve) 750 mg x1, then reduce to 250 mg Q8H until attack resolved
–> avoid in severe renal disease, cardiac disease, bleeding
Acute gout tx: Colchicine
(Colcrys)
–> flare tx: 1.2 mg at the first sign of flare, in 1 hr single 0.6 mg then 0.6 mg daily or BID (only if symptoms began within 36 hrs)
–> Prophylaxis: 0.6 mg qd or BID (max 1.2 mg/day)
SEs: loose stools, N/V, myelosuppression and neuromyopathy and death possible if overdosed!
CI: with clarithyomycin (CYP3A4 inhib) and cyclosporine (P-gf sub)
-myopathy and rhabdomyolysis if taken w/ a statin (do not take with gemfabazol)
Gout Treatment Basics*
Asymptomatic hyperuricemia is NOT treated w/ drugs (only when attack has occured)
Treat acute pain with anti-inflammatory drugs:
–> Colchicine
–> Steroids (including intra-articular injections)
–> NSAIDs (often with a higher starting dose)
Treat chronically to prevent future attacks:
–> allopurinol or febuxostat
If UA remains > 6 and pt is on tx, add:
–> probenecid or lesinurad daily
–> replace XOI with IV pegloticase (Krystexxa)
Acute Gout tx: steroids
-steroids can be given PO,IM,Iv intra-articular or via ACTH (Corticotropin) which triggers endogenous glucocorticoid secretion
–> Prednisone
–> Methylprednisolone (Medrol)
–> Triamcinolone
-start high, then cut the dose down (taper)
SEs: inc BG, BP, appetite
-intra articular: localized joint damage
Chronic gout tx: Xanthine Oxidase Inhibitors (XOI)
-blocks uric acid production, titrate to UA < 6 mg/dL
–> Allopurinol (Zyloprim): 50-100 mg daily (lower doses for CKD- 50)
-allopurinol hypersensitivity syndrome (AHS): severe rash, fever, eosinophilia, hepatitis & renal failure - test for HLA-B*5801
–> Febuxostat (Uloric) 40-80 mg qd, more $, may be safer in severe renal impairment, def risk for hypersen. rxn
For both: monitor for liver damage, precipitation of acute attacks, nausea and skin rash
Chronic gout tx: Uricosurics
-increase excretion of uric acid in the urine, require adequate renal function
–> Probenecid
–> Lesinurad (Zurampic)
Chronic Gout tx: Recombinant Uricase
-converts uric acid to allantion, allows for excretion
–> Pegloticase (Krystexxa)
-IV q 2 weeks
-anaphylaxis possible: pre-medicate with antihistamines and steroids
-do not use in combination with allopurinal or febuxostat
Tumor Lysis Syndrome
-due to cell lysis and purine released to the blood = converted to uric acid –> acute gout and electrolyte abnormalities
–> allopurinol for prevention
–> rasburicase (Elitek) for tx
