Pain Management

Question 1

Side effects of NSAIDs

Answer 1

Bleeding/ platelet aggregation
Peptic ulcer disease and dyspepsia
Acute Renal failure/ nephropathy
Fluid retention (HPT)
Bronchoconstriction (asthma)
Hepatotoxic
Hypersensitivity

Question 2

MOA of NSAIDs

Answer 2

Cox inhibitors, then decreased prostaglandin synthesis then less inflammation

Question 3

Adverse effects of morphine

Answer 3

Nausea
Sedation
Constipation
Resp depression

Histamine release: vasodilatation, Bronchoconstriction, itching

Question 4

MOA of Tramadol

Answer 4

Parent drug and active metabolite u receptor agonist
Inhibits reuptake of serotonin and noradrenaline

Question 5

Drug interactions of Tramadol

Answer 5

Combined with SSRIs cause Serotonin syndrome
Carbamezapine induces metabolism of Tramadol