Pain & Headache Pharmacology

Question 1

Naproxen

Answer 1

NSAIDs

Question 2

Celecoxib

Answer 2

COX-2 selective inhibitor

Question 3

Acetaminophen

Answer 3

COX-2 inhibitor (CNS)

Question 4

Morphine

Answer 4

Opioid mu-agonist

Question 5

Hydrocodone

Answer 5

Opioid-mu agonist

Question 6

Oxycodone

Answer 6

Opioid-mu agonist

Question 7

Codein

Answer 7

Opiod-mu agonist

Question 8

Tramadol

Answer 8

Opoid-mu agonist

Question 9

Fetanyl

Answer 9

Opioid-mu agonist

Question 10

Pharcokinetics of Opioid-mu agonist (3)

Answer 10

1. more effective parenterally
2. Rapidity of onset: lipid solubility and abuse potential
3. Metabolize in liver; excreted in kidney

Question 11

Why Opioid-mu agonist more effective if given parenterally?

Answer 11

due to first pass metabolism

Question 12

Adverse reaction of Opioid-mu angonist (5)

Answer 12

1. Respiratory Depression –> caution with asthma, emphysema…
2. Nausea/vomiting
3. Constipation
4. Pupillary constriction
5. Urinary retention

Question 13

Ketamine, Memantine

Answer 13

NMDA-antagonist

Question 14

Pregabalin, Gabapentin

Answer 14

alpha-2-delta ligand

Question 15

Buprenorphine

Answer 15

partial mu-agonist

Question 16

Treatment for SEVERE Neuropathic pain (3)

Answer 16

1. Tramadol
2. Buprenorphine
3. Opioid (last resource)

Question 17

Treatment for MILD-MODERATE Neuropathic pain (3)

Answer 17

1. NMDA-antagonist & Anticonvulsant
2. NSAID & LAs
3. Tricyclic anti-depression