Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

NeuroAnatomy Fall 2015 > NeuroPharmacology > Flashcards

NeuroPharmacology Flashcards

1
Q

What is the therapeutic action (ThA) of Adrenergic (SNS) Agonist on GI/GU? Be sure to mention the receptors. (3)

A
  1. beta 2-3: smooth muscle relaxation (bladder)
  2. alpha 1: close sphincter –> promote continence
  3. beta 2: uterine relaxation –> premature labor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ThA of PNS Agonist on GI/GU? (3)

A
  1. M: increase salivation [Xerostomia]
  2. M: increase detrusor contraction [increase urinary flow]
  3. M: increase motility [paralytic ileus]
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Side effects (SE) of PNS agonist on GI/GU? (1)

A

Diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

SE of PNS Antagonist on GI/GU? (3)

A
  1. Dry mouth
  2. Urinary hesitancy-retention
  3. Constipation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ThA of PNS Antagonist on GI/GU? (3)

A
  1. Decrease salivation [create dry field]
  2. Block Detrusor [overactive bladder]
  3. Decrease GI motility [diarrhea]
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ThA of SNS Antagonist on GI/GU? (1)

A

alpha 1: open sphincter (ease voiding) [Micturition Disorders, BPH]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the drawbacks of using atropine as treatment of cholinesterase inhibitor?

  1. Nerve gas toxicity
  2. Mushroom toxicity
A
  1. Nerve gas toxicity: at Muscarinic only, NOT effect at NMJ

2. NOT effective at muscarine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adverse reaction of Direct-acting Cholinergic Agonist?

Hint: SLUDGE

A 
S - Salivation
L - Lacrimation
U - Urination
D - Defecation
G - GI --> cramping, emesis
E - Eye --> miosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Antidote for excessive muscarinic receptor stimulation? (1)

A

Atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

List of organs in order of most sensitive to least sensitive to muscarinic blocking agents.

A
  1. Exocrine gland –> dry mouth
  2. Sweat gland –> increased body temperature
  3. Heart –> tachycardia
  4. Eye –> blurred vision, increased IOP
  5. Lung –> bronchodilation
  6. Genitourinary tract –> urinary retention
  7. Gastrointestinal tract –> constipation
  8. CNS effects
  9. Overdose toxicity (infants and children especially) –> high fever
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

List 2 contraindications to use cholinergic antagonist?

A
  1. Glaucoma - may cause blindness in acute narrow angle glaucoma
  2. Benign prostatic hyperplasia - aggravate symptoms of urinary retention
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pilocarpine & Bethanechol

A

PNS Agonist (M)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Neostigmine

A

PNS Agonist (AChE in)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Pyridostigmine

A

PNS Agonist (AChE in)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Edrophonium

A

PNS Agonist (AChE in)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Physostigmine (Eg: Donepezil)

A

PNS Agonist (AChE in)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Organophosphate Nerve Gas

A

PNS Agonist (AChE in)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Atropine

A

PNS Antagonist (M)

19
Q

Scopolamine

A

PNS Antagonist (M)

20
Q

Oxybutynin

A

PNS Antagonist (M)

21
Q

Tolterodine

A

PNS Antagonist (M)

22
Q

Ipratropium & Tiotropium

A

PNS Antagonist (M)

23
Q

Common COPD Treatment

A

Ipratropium & Tiotropium

24
Q

List 2 examples of Curare

A
  1. Atracurium

2. Rocuronium

25
Q

Atracurium

A

PNS Antagonist (Nicotinic-M)

26
Q

Rocuronium

A

PNS Antagonist (Nicotinic-M)

27
Q

Epinephrine

A

SNS Agonist (a1-b1-b2)

28
Q

Norepinephrine

A

SNS Agonist (a1-b1)

29
Q

Isoproterenol

A

SNS Agonist (b1-b2)

30
Q

Albuterol

A

SNS Agonist (b2)

31
Q

Phenylephrine

A

SNS Agonist (a1 selective)

32
Q

Dobutamine

A

SNS Agonist (b1)

33
Q

Pseudoephedrine

A

SNS Agonist (reverse NET prevent re-uptake)

34
Q

Dopamine

A

SNS Agonist (D1)

35
Q

Amphetamine

A

Indirect CNS Agonist (releaser)

36
Q

Prazosin-Doxazosin-Terazosin

A

SNS Antagonist (a1)

37
Q

Metoprolol-Atenolol

A

SNS Antagonist (b1)

38
Q

Propranolol

A

SNS Antagonis (b1-b2)

39
Q

Labetalol-carvedilol

A

SNS Antagonist (a1-b1-b2)

40
Q

Nerve Gas Poisoning Antidote (4)

A
  1. Pralidoxime
  2. Atropine
  3. Diazepam
  4. Mechanical ventilation
41
Q

Pralidoxime MoA

A

Regenerates AChE (antiCholinergic)

42
Q

Atropine Therapeutic Action (3)

A

Treat

  1. Bradycardia
  2. Bronchospam
  3. Bronchorrhea
43
Q

Diazepam Therapeutic Action

A

Prevent or treat convulsion

44
Q

List 3 drugs commonly used for nasal decongestion

A
  1. Pseudoephedrine
  2. Phenylephrine
  3. Oxymetazoline

NeuroAnatomy Fall 2015 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions