pain Flashcards
Oligoanesthesia- who is at risk
under-treatment of pain
• Peds, elderly, cognitive delay, psych pt’s, altered
Know three rule
• Know three drugs for each class and route
3 CCB for HTN
3 Medicines parenteral for pain
3 NSAIDS
3 Long Acting insulin
not everybody is the correct profile. the third medicine should always be “what if they are pregnant”
pain treatment is separate in what dx
• Pain treatment is separated in cancer and non-cancer pain
Cancer pain – don’t worry about addiction (just treat their pain which generally terrible pain)
Symptomatic vs. Mechanism approach
Treating the mechanism of pain is treating the nerve pathways/physiology of pain
Parenteral includes
IM SQ IV
onset of IM
easy, onset 10-20 min, lasts longer; stick is involved, not titrateable, results are unpredictable. Can give someone 8mg of morphine IM and they may not feel anything and want more.
IV advantages
what situations are pest
Fast onset, titrateable; stick, shorter duration, more side effects.
Good if: moderate/severe, NPO, or local pain control not possible. Best overall
advantages and disadvantages of PO
i. Easy, long duration; delayed onset, can’t give if vomiting, NPO or significant pain
Local infiltration/blocks advantages
i. Fast onset, lasts 1-4hrs*, good duration for procedures – lacs, abscess, foreign body, digital block, ring block, dental blocks
when would acetaminophen be used
- IV: 1g excellent; Oral: 1gm; Rectal in kids
- Great antipyretic, good analgesia
- Combine w/ NSAID’s, opiates - anything
- Good for most elderly/pregnant pt’s
when is acetaminophen CI
Avoid: liver FAILURE, big etoh
NOT liver disease
• NSAIDs are CI in
Over 65yo (but if youre going to give it, give the lowest dose), renal or GI issues, on ASA/coumadin, bleeding issues, pregnant, breastfeeding. Avoid Cox-2’s
NSAID dose
• Oral: Ibuprofen 600-800mg, Naprosyn 500mg, etc
800 NO significant benefit
can use NSAIDS with
Combo: APAP/NASIDs to treat acute pain
Ketorolac (Toradol®) what kind of drug is it
how is it administered
IM/IV 15-30mg (you will see 30 and 60 mg)
NSAIDS
Ketorolac (Toradol®) is best for
NSAIDS
Great: back pain, renal colic, muscles, burns, etc
Ketorolac (Toradol®) should be avoided in
Avoid: Over 65yo (but if youre going to give it, give the lowest dose) renal or GI issues on ASA/coumadin bleeding issues pregnant breastfeeding. Avoid Cox-2’s
what are the limitations with ketorolac
More not better. Give 1-2x max in ED. 5 days inpatient max
Benefits of Ketoralc over NSAIDs
sometimes better for acute pain
better for placebo of IM
Gabapentin (Neurontin®)
what are the other drugsin this class dosed
nerve pain medication
Oral dosing only
Pregabalin, Duloxetine
Gabapentin can be used with
Gabapentin
combo with
NSAIDs/APAP for acute pain
but CAN’T DRIVEAFTER
Gabapentin typically given for
Neuropathic pain –
DM, fibromyalgia, post herpetic neuralgia, back pain
Tramadol (Ultram®)
• Synthetic, opiate-like activity
- Addiction/abuse potential
- . Not often used in ED for acute pain, not often rx’d
opiates are schedule
what are the indications
Opium-derived drugs: alkaloids, semisynthetic
. Parenteral are Schedule IV – pt specific order
iv. Indications: moderate – severe pain
Biggest ADE’s/concerns with opiates
i. Respiratory depression: all
ii. Hypotension; esp w/ Morphine
iii. Altered mental status, dizzy
iv. Nausea/vomiting common
v. ADE: flushing, rash, itching
vi. Constipation
vii. Tolerance/dependence/addiction
opiatesa are given with (3)
IV-pump up your blood pressure
antiemetics-keep you from barfing
antihistamines -reduce rash and flush
dosing or morphine
Dose 4-10mg IM/IV common
comes in 2’s be mindful of this
order 2, 4, 6, 8 or 10
really don’t use 2 or 10
because it comes in 2s DO NOT ORDER 5
8 is high
usually we giver 4 or 6
10mg is .1 fentanyl and 1.5 hydromorphone
onset is 10-15 minutes
morphine is CI in
hypotensive
USE ANOTHER DRUG
• AMS common; careful in resp dz, elderly, kids
Hydromorphone (Dilaudid®) dosing
Dose 0.5-1mg IV (0.5 novice, 1mg severe pain)
PO dose 1-2mg – good if no IV, can take PO
IM NOT so good
very slow onset
CI with dilaudid
Hypotension less – but still a concern; AMS
really high abuse potential
IV onset of dilaudid
• IV onset <10min, lasts ~2hrs unless tolerance
fentanyl compared to morphine
Powerful analgesic: 80-100x more potent than Morphine
fentanyl order
IM/IV 1-2mcg/kg (25-100mcg) (that’s micrograms)
bigget benefit of fentanyl
Biggest benefit is NO hypotension – great choice in these pt’s
SE of fentanyl
Respiratory depression, GI effects common – give O2, antiemetic too
CI of fentanyl
Contraindicated if pt takes MAOI’s
why is fentanyl good choice for kids
Good in kids – intranasal/IM/IV – double check dose
duration of fentanyl
Short duration of effect: +/- 1hr; re-dosing common
IM/IV 1-2mcg/kg (25-100mcg) (that’s micrograms)
Meperidine (Demerol®) CI with
- Contraindicated w/ MAOI’s:
* Removed from most ED’s: safety, abuse potential
methadone works for addiction by
• Blocks the “high”, reduces cravings and withdrawal sx’s
methadone can be used for pain associated with
Effective for cancer pain, not first-line in non-cancer pain
Emerging usefulness in ED as oral alternative if using opiates – very long effect
Common Rx for moderate pain in ED if can take PO
Vicodin/Norco/Lortab (Hydrocodone + APAP)
Tylenol w/ Codeine
AVOID Oxycodone and Percocet
dosing of vicodin and norco
Vicodin 5/500 (5 hydrocodone and 500 Tylenol)
Norco 5/325 – avoid higher doses in ED
vicodin given for outpatient
As outpatient, short term Rx (#8-10 MAX)
2 tablets every 6 hours treats three days worth of pain
concerns with Vicodin rx
- Constipation – Rx with Senna, Colace
- Goal is to avoid opiates altogether!
- Most ED’s do not refill oral opiates – check policy
why would Tylenol w/ Codeine be preferred in kids
- Tylenol #3 (30/300), less potent than Vicodin/Norco
3. Elixir 12/120mg per 5ml: useful in kids (adjust dose); or if can’t swallow pills
Common ADE’s of opiates include:
i. Hypotension
ii. Nausea/vomiting
iii. Histamine release
f. Antiemetics that can be administered for opiate RX
Zofran 4-8mg IV/IM/SL
Metoclopramide 5-10mg IV/IM
Phenergan 12.5-25mg IV/IM/PR
Compazine 5-10mg IV/IM/PR
Anxiolytics (Benzos), name three
Lorazepam (Ativan®) 0.5-1mg IM/IV
Midazolam (Versed®) 2-4mg IM/IV: very short acting, very sedating
Benzos: offer no analgesia but will lower blood pressure
antihistamines given wiht opiates
i. Benadryl 25-50mg IM/IV
Ketamine
Trance-like” state; analgesia, amnestic
ketamine used to be used for
Was mostly for procedural sedation, until now. “The first 500”
iii. Low doses for acute pain in adults (LDK = low dose ketamine)
dosing for ketamine
- IM 0.5-1mg/kg, IV 0.1-0.6mg/kg, IN 0.5mg/kg