Pain Flashcards
What type of feeling do AB-fibers transduce?
Touch and pressure 2nd fastest (35-75 m/s)
What type of feeling do AD-fibers transduce?
Pain and cold
They are myelinated so very fast
Sharp, prickly pain
What type of feeling do C-fibers transduce?
Pain, temperature, touch, pressure, and itch
Unmyelinated, so slow
“second pain”: dull and aching
What is substance P?
It plays a role in heightening pain response.
It causes vasodilation, degranulation of mast cells, and release of histamine and prostaglandins
Increases the expression of pain receptors in the periphery
Acetaminophen pediatric dosing
10-15 mg/kg q4 prn
Ibuprofen pediatric dose
5-10 mg/kg q6 prn
30mg oral morphine= ? fentanyl
0.1mg fentanyl
30mg oral morphine= ? hydrocodone
30mg hydrocodone
30mg oral morphine= ? parenteral hydromorphone
1.5 mg parenteral (IV) hydromorphone
30mg oral morphine= ? oral hydromorphone
7.5mg oral hydromorphone
30mg oral morphine= ? oxycodone
20 mg oxycodone
1.5 mg IV hydromorphone= ? oral hydromorphone
7.5 mg oral hydromorphone
10 mg IV morphine= ? oral morphine
30mg oral morphine
What receptor do opioids act on?
mu
What receptor does LSD, mushrooms (psilocybin, psilocin) act on?
Serotonin receptor
What receptor does marijuana/K2/spice act on?
CB1 receptor
What receptor does caffeine act on?
adenosine
What receptor do amphetamines/ecstacy/mdma act on?
DAT, NET, SERT substrates
meth also pushes DA out of vesicles and into the synapse
What receptor does cocaine act on?
DAT and SERT and NET inhbitor
What receptors does alcohol act on?
GABA channels, release of endogenous opioids, serotonin, NMDAR, KiR3
What receptor does nicotine act on
ionotropic acetylcholine receptors
What receptor does PCP/Ketamine act on?
Ionotropic NMDA receptor (antagonist)
What receptor do benzos and barbiturates act on?
ionotripic GABA receptors
They are PAMs
