Pain

Question 1

What type of feeling do AB-fibers transduce?

Answer 1

Touch and pressure
2nd fastest (35-75 m/s)

Question 2

What type of feeling do AD-fibers transduce?

Answer 2

Pain and cold
They are myelinated so very fast
Sharp, prickly pain

Question 3

What type of feeling do C-fibers transduce?

Answer 3

Pain, temperature, touch, pressure, and itch
Unmyelinated, so slow
“second pain”: dull and aching

Question 4

What is substance P?

Answer 4

It plays a role in heightening pain response.
It causes vasodilation, degranulation of mast cells, and release of histamine and prostaglandins
Increases the expression of pain receptors in the periphery

Question 5

Acetaminophen pediatric dosing

Answer 5

10-15 mg/kg q4 prn

Question 6

Ibuprofen pediatric dose

Answer 6

5-10 mg/kg q6 prn

Question 7

30mg oral morphine= ? fentanyl

Answer 7

0.1mg fentanyl

Question 8

30mg oral morphine= ? hydrocodone

Answer 8

30mg hydrocodone

Question 9

30mg oral morphine= ? parenteral hydromorphone

Answer 9

1.5 mg parenteral (IV) hydromorphone

Question 10

30mg oral morphine= ? oral hydromorphone

Answer 10

7.5mg oral hydromorphone

Question 11

30mg oral morphine= ? oxycodone

Answer 11

20 mg oxycodone

Question 12

1.5 mg IV hydromorphone= ? oral hydromorphone

Answer 12

7.5 mg oral hydromorphone

Question 13

10 mg IV morphine= ? oral morphine

Answer 13

30mg oral morphine

Question 14

What receptor do opioids act on?

Answer 14

mu

Question 15

What receptor does LSD, mushrooms (psilocybin, psilocin) act on?

Answer 15

Serotonin receptor

Question 16

What receptor does marijuana/K2/spice act on?

Answer 16

CB1 receptor

Question 17

What receptor does caffeine act on?

Answer 17

adenosine

Question 18

What receptor do amphetamines/ecstacy/mdma act on?

Answer 18

DAT, NET, SERT substrates

meth also pushes DA out of vesicles and into the synapse

Question 19

What receptor does cocaine act on?

Answer 19

DAT and SERT and NET inhbitor

Question 20

What receptors does alcohol act on?

Answer 20

GABA channels, release of endogenous opioids, serotonin, NMDAR, KiR3

Question 21

What receptor does nicotine act on

Answer 21

ionotropic acetylcholine receptors

Question 22

What receptor does PCP/Ketamine act on?

Answer 22

Ionotropic NMDA receptor (antagonist)

Question 23

What receptor do benzos and barbiturates act on?

Answer 23

ionotripic GABA receptors

They are PAMs