Pain

Question 1

NSAIDs

Answer 1

inhibit s PG (Cox 1 and Cox 2)

Question 2

Inhibition of Cox 2

Answer 2

suppression of edema
alleviation of pain
reduction of fever

Question 3

inhibition of Cox 1

Answer 3

GI - increased acid, heartburn –> bleeding
Renal - decreased blood flow to kidneys –>renal impairment
Pulmonary - asthma

Question 4

Indications of NSAIDs

Answer 4

pain associated w/musculoskeletal: RA, OA, tendonitis, sprain
HA
inflammation
fever, dsymenorrhea

Question 5

contraindications of NSAID

Answer 5

allergy
PUD
renal impairment

Question 6

Reye’s syndrome

Answer 6

• aspirin reaction in young children
• ASA w/viral infections (chicken pox, flu)
• use acetominophen for fever
• leads to liver failure

Question 7

salicylism

Answer 7

OD of ASA
when ASA levels > therapeutic level
S/Sx - tinnitus, sweating, HA, dizziness, respiratory alkalosis (hyperventilate to get ride of CO2)
- CNS depression, seizure, coma
- hyperthermia, dehydration

Rx to excrete - charcoal (if early)

• sodium bicarb to neutralize acidity of ASA
• lots of fluids

Question 8

opioids

Answer 8

mimic opioids at Mu and Kappa receptors

Question 9

pure opioid

Answer 9

attaches to both mu and kappa receptors

Question 10

partial or mixed opioid

Answer 10

mu agonist or kappa agonist
only attaches to one receptor
given to drug addicts - helps w/pain w/o “high” feeling