Pain Flashcards
Definition of pain?
an unpleasant sensory and emotional experience arising from actual or potential tissue damage, as warning signal to react to stimuli withdraw from harm.
What are the 2 categories of Pain?
Neuropathic and nociceptive
What is neuropathic pain?
The abnormal processing of stimuli from the peripheral or central nervous systems and is thought to have no purpose
What is nociceptive pain?
Normal neural processing of pain that occurs when free nerve endings are activated by tissue damage or inflammation.
Can be acute, chronic or primary chronic.
What are the 4 processes of Nociceptive pain?
Transduction, Transmission Perception and Modulation
What is transduction? (NP)
Tissue damage which releases chemical mediators such as prostaglandins, bradykinin, serotonin, substance P and histamine. Which go on to activate nociceptors= transduction or generation of an action potential(electrical impulse)
What is transmission?
Action potential moves from the site of injury along afferent nerve fibres to nociceptors at the spinal cord. Release of substance P and other neurotransmitters carries the AP across the cleft to the dorsal horn of the spinal cord, where it ascends the spinothalmic tract to the thalamus and the midbrain. From the thalamus, fibres send the nociceptive message to the somatosensory cortex, parietal lobe, frontal lobe and the limbic system- where perception occurs
What is perception?
The conscious experience of pain involves both the sensory and affective components of pain.
The limbic system, at the area if the anterior cingulated gyrus, produces the emotional response to the pain, activation of the midbrain leading to the modulation as the final nociceptive process.
What is modulation?
Multiple types of neurons from this area that have a variety of neurotransmitters (including endorphins, enkephalins, serotonin (5-HT) and dynorphin) descend to lower areas in the central nervous system.
Neurons stimulate the release of additional neurotransmitters, which ultimately trigger the release of endogenous opioids and inhibit transmission of the pain impulse at the dorsal horn.
Acute pain is typically self-limiting and resolves after the noxious stimulus has been removed, but inflammatory and other mechanisms may lead to persistence of nociceptive pain for weeks, months, or years (i.e. chronic pain).
What are the three types of pain assessment?
Numeric or Graphic rating scale (NRGS)- 0-10 where 10 is the worst pain imaginable.
Visual Analog scale (VAS)- 10cm line- patient is asked to place mark where current pain intensity is.
Verbal descriptor scale (VDS)- verbal descriptors e.g. no pain, mild pain, moderate pain, severe pain etc.
MOA for opioids?
That act by binding to, and activating specific receptor sites in the central and peripheral nervous systems. Once these receptor sites are activated, pain signal transmission is blocked through several mechanisms, producing analgesia.
Examples of μ opioids
Morphine, fentanyl, oxycodone and hydromorphone
Most common side effects of opioids?
Nausea, vomiting, pruritus, constipation and sedation
What should be given to a patient to prevent opioid induced constipation?
stool softener + laxative
What is the most serious side effect of opioid analgesics and what should be monitored ?
respiratory depression
Patients respiratory status should be performed regularly within the first 24 hours of opioid therapy.
