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Naplex Drug Card > PAH Drugs > Flashcards

PAH Drugs Flashcards

1
Q

Sprycel

A

Dasatinib
(Causes PAH)

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2
Q

Proglycerin

A

Diazoxide
(Causes PAH)

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3
Q

Fintepla

A

Fenfluramine
(Causes PAH)

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4
Q

Flolan, Veletri

A

Epoprostenol
(Prostacyclin analogue and receptor agonist)

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5
Q

Remodulin (continous SC or IV)

Tyvaso (inhalation)

Orenitram (oral, ER tablet)

A

Treprostinil

(Prostacyclin analogue and receptor agonist)

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6
Q

Ventavis (inhalation)

A

Iloprost

(Prostacyclin analogue and receptor agonist)

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7
Q

Uptravi (tablet)

A

Selexipag

(Prostacyclin analogue and receptor agonist)

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8
Q

HF contraindications

A

(Prostacyclin analogue and receptor agonist)

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9
Q

Contraindications child-pugh class C

A

Treprostinil

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10
Q

Vasodilatory side effect
Sepsis/Bactermia
Jaw pain
Rebound PH
Increased bleeding risk

A

Prostacyclin analogue and receptor agonist

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11
Q

Short half life and requires back up pump/drugs

A

Epoprostenol
Treprostinil

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12
Q

Requires protection from light

A

Epoprostenol

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13
Q

Requires ice pack for stability after reconstitution

A

Flolan (Epoprostenol)

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14
Q

Level affected by 2C8 inhibitors and inducers

A

Treprostinil
Selexipag

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15
Q

Tracleer

A

Bosentan
(endothelin receptor antagonist)

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16
Q

Letairis

A

Ambrisetan
(endothelin receptor antagonist)

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17
Q

Opsumit

A

Macitentan

(endothelin receptor antagonist)

18
Q

< 40kg: 62.5 BID
>= 40kg: 62.5 BID x 4weeks —> 125mg BID

A

Bosentan

19
Q

5mg daily may increase to 10mg after 4 weeks

A

Ambrisetan

20
Q

10 mg daily

A

Macitetan

21
Q

Requires REMS
Teratogenic
Hepatotoxicity
Reduces H&H

A

(endothelin receptor antagonist)

22
Q

Hypersensitivity reaction
3A4 and 2C9 substrate and inhibitors
Reduces contraceptive effectiveness
Avoid with cyclosporine and glyburide
Greater risk of hepatotoxicity
Approved for 3 yrs and older

A

Bosentan

23
Q

Avoid in idiopathic pulmonary fibrosis
3A4, 2C19 and P-gp substrate

5mg daily if with cyclosporine

A

Ambrisentan

24
Q

3A4 and 2C19 substrate

A

Macitetan

25
Q

Reviatio (PAH)

Viagra (erectile dysfunction)

A

Sildenafil

(PDE-5 inhibitors)

26
Q

Adcirca, Alvq (PAH)

Cialis (erectile dysfunction)

A

Tadalafil

27
Q

Tablet, oral suspension, IV

A

Revatio

28
Q

Avoid renal and hepatics impairments
Avoid with alpha-blockers

A

Adcirca, Alvq

29
Q

Avoid with protease inhibitors

A

Reviatio

30
Q

Avoid with nitrates and alcohol
Caution with alpha blocker
Major 3A4 substrate

A

(PDE-5 inhibitors)

31
Q

Vasodilation effects
Praipism
Epistaxis
Eye and Ear loss

A

(PDE-5 inhibitors)

32
Q

Adempas

A

Riociguat
(Soluble guanylate cyclase stimulator)

33
Q

Major 3A4, 2C8, & P-gp substrate

A

Riociguat

34
Q

Teratogenic
Requires REMS
Avoid with PDE5i and nitrates
Separate from antacids > 1 hour
Smoking decreases clearance

A

Riociguat

35
Q

Separate from sildenafil by 24hrs and tadalafil by 48 hrs

A

Riociguat

36
Q

Max dose 2.5 mg if SBP > 95 mmHg

A

Riociguat

37
Q

Approved for PAH and CTEPH

A

Riociguat

38
Q

Amiodarone/Dronedarone
Bleomycin
Busulfan
Carmustine/Lomustine
Nitrofurantoin
Sulfasalazine

A

Causes pulmonary fibrosis

39
Q

Esbriet

A

Pirfenidone
(Approved for pulmonary fibrosis)

40
Q

Ofev

A

Nintedanib
(Approved for pulmonary fibrosis)

Naplex Drug Card (6 decks)

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