Drug Use In Pregnancy And Lactation Flashcards
Average pregnancy cycle
37-40 weeks
Time for most organ development
0-12 weeks
Most likely time for teratogenicity to occur
0-12 weeks
What drives drug dose or regimen adjustment during pregnancy
Pharmacokinetics changes that occur during pregnancy
Gravida (G)
Number of pregnancies
Para (P)
Number of births
Folic acid dose in pregnancy
600 DFE/day
Calcium dose in pregnancy
1000 mg/day
(Babies will consume mothers bone for calcium during development)
Vit D dose in pregnancy
600 IU/day
Recommended vaccination during pregnancy
Inactive influenza
Single dose Tdap/pregnancy
Avoid live vaccination
Drug information resources for pregnant
Briggs drugs in pregnancy and lactation
Key teratogenic drugs in pregnancy: Acne
Isotretinoin
Topical retinoids
Key teratogenic drugs in pregnancy: antibiotics
Fluoroqunolone
Tetracycline
Aminoglycosides
Key teratogenic drugs in pregnancy: anticoagulants
Warfarin
Key teratogenic drugs in pregnancy: Dyslipidemia/HF/Cardio
Statins
ACEi/ARB/Aliskeren/Entresto
Amiodarone/Dronedarone
Atenolol
Key teratogenic drugs in pregnancy: Hormones
All hormone containing agent
Duavee
Key teratogenic drugs in pregnancy: Migraine
Digydroergotamine
Ergotamine
Key teratogenic drugs in pregnancy: AED
Topiramate
VPA/Divalproex
Carbamazepine
Phenobarbital
Phenytoin
Key teratogenic drugs in pregnancy: others
Hydroxyurea
Lithium
Methotrexate
NSAIDs
Misoprostol
Paroexetine
Weight loss drugs
Ribavirin
Key teratogenic drugs in pregnancy: others part 2
BZD
Dutasteride
Finasteride
Fluconazole
Voriconazole
MMI/PTU
Radioactive iodine
Elevated BP + organ failure
Preeclampsia
Elevated BP + organ failure + seizure + death
Eclampsia
Low dose aspirin at the end of the first trimester
To prevent preeclampsia
Risk factors for preeclampsia
HTN
T1/2D
Renal disease
Hx of preeclampsia