Pages 220-223 Flashcards
Acanthosis nigricans (hyperpigmentation and epidermal thickening)
Visceral malignancy (esp. stomach)
Actinic keratosis
Squamous cell carcinoma of skin
AIDS
Aggressive malignant lymphomas (non-Hodgkin’s) and Kaposi’s sarcoma
Autoimmune diseases (e.g., Hashimoto thyroiditis, SLE)
Lymphoma
Barrett esophagus (chronic GI reflux)
Esophageal adenocarcinoma
Chronic atrophic gastritis, pernicious anemia,
postsurgical gastric remnants
Gastric adenocarcinoma
Cirrhosis
Hepatocellular carcinoma
Cushing syndrome
Small cell lung cancer
Dermatomyositis
Lung cancer
Down syndrome
ALL (“we ALL fall Down”), AML
Dysplastic nevus
Malignant melanoma
Hypercalcemia
Squamous cell lung cancer
Immunodeficiency states
Malignant lymphomas
Lambert-Eaton myasthenic syndrome
Small cell lung cancer
Myasthenia gravis, pure RBC aplasia
Thymoma
Paget disease of bone
2° osteosarcoma and fibrosarcoma
Plummer-Vinson syndrome (r iron)
Squamous cell carcinoma of esophagus
Polycythemia
Renal cell carcinoma, hepatocellular carcinoma
Radiation exposure
Leukemia, sarcoma, papillary thyroid cancer, and breast cancer
SIADH
Small cell lung cancer
Tuberous sclerosis (facial angiofibroma, seizures, intellectual disability)
Giant cell astrocytoma, renal angiomyolipoma, and cardiac rhabdomyoma
Ulcerative colitis
Colonic adenocarcinoma
Xeroderma pigmentosum, albinism
Melanoma, basal cell carcinoma, and especially squamous cell carcinomas of skin
BCR-ABL
ASSOCIATED TUMOR
GENE PRODUCT
CML, ALL
Tyrosine kinase
bcl-2
ASSOCIATED TUMOR
GENE PRODUCT
Follicular and undifferentiated lymphomas
Anti-apoptotic molecule (inhibits apoptosis)
BRAF
ASSOCIATED TUMOR
GENE PRODUCT
Melanoma
Serine/threonine kinase
c-kit
ASSOCIATED TUMOR
GENE PRODUCT
Gastrointestinal stromal tumor (GIST)
Cytokine receptor (for stem cell factor)
c-myc
ASSOCIATED TUMOR
GENE PRODUCT
Burkitt lymphoma
Transcription factor
HER2/neu (c-erbB2)
ASSOCIATED TUMOR
GENE PRODUCT
Breast, ovarian, and gastric carcinomas
Tyrosine kinase
L-myc
ASSOCIATED TUMOR
GENE PRODUCT
Lung tumor
Transcription factor
N-myc
ASSOCIATED TUMOR
GENE PRODUCT
Neuroblastoma
Transcription factor
ras
ASSOCIATED TUMOR
GENE PRODUCT
Colon cancer, lung cancer, pancreatic cancer
GTPase
ret
ASSOCIATED TUMOR
GENE PRODUCT
MEN 2A and 2B
Tyrosine kinase
APC
ASSOCIATED TUMOR
Colorectal cancer (associated with FAP)
BRCA1 +2
ASSOCIATED TUMOR
GENE PRODUCT
BRCA1 Breast and ovarian cancer
BRCA2 Breast and ovarian cancer
DNA repair protein
DPC4/SMAD4
ASSOCIATED TUMOR
GENE PRODUCT
Pancreatic cancer
DPC—Deleted in Pancreatic Cancer
DCC
ASSOCIATED TUMOR
GENE PRODUCT
Colon cancer
DCC—Deleted in Colon Cancer
MEN1
ASSOCIATED TUMOR
MEN type I