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First Aid Step 1 Rapid Review > Page 210 > Flashcards

Page 210 Flashcards

1
Q

Epoetin alfa (erythropoietin)

Clinical uses

A

Anemias (especially in renal failure)

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2
Q

Thrombopoietin

Clinical uses

A

Thrombocytopenia

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3
Q

Oprelvekin (interleukin-11)

Clinical uses

A

Thrombocytopenia

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4
Q

Filgrastim (granulocyte colony-stimulating factor)

Clinical uses

A

Recovery of bone marrow

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5
Q

Sargramostim (granulocyte-macrophage colony-stimulating factor)

Clinical uses

A

Recovery of bone marrow

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6
Q

Aldesleukin (interleukin-2)

Clinical uses

A

Renal cell carcinoma, metastatic melanoma

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7
Q

IFN-α

Clinical uses

A

Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

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8
Q

IFN-β

Clinical uses

A

Multiple sclerosis

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9
Q

IFN-γ

Clinical uses

A

Chronic granulomatous disease

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10
Q

Alemtuzumab

Target/clinical use

A

CD52

CLL
“Alymtuzumab”—chronic lymphocytic leukemia

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11
Q

Bevacizumab

Target/clinical use

A

VEGF

Colorectal cancer, renal cell carcinoma

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12
Q

Cetuximab EGFR

Target/clinical use

A

Stage IV colorectal cancer, head and neck cancer

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13
Q

Rituximab

Target/clinical use

A

CD20

B-cell non-Hodgkin lymphoma, rheumatoid arthritis (with MTX), ITP

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14
Q

Trastuzumab

Target/clinical use

A

HER2/neu

Breast cancer, gastric cancer

HER2—“tras2zumab”

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15
Q

Infliximab, adalimumab

Target/clinical use

A

TNF-α

IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis

Rheumatoid arthritis “inflix” pain in “da limbs”

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16
Q

Natalizumab

Target/clinical use

A

α4-integrin

Multiple sclerosis, Crohn disease

α4-integrin: leukocyte adhesion
Risk of PML in patients with JC virus

17
Q

Abciximab

Target/clinical use

A

Glycoprotein IIb/IIIa

Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

IIb times IIIa equals
“absiximab”

18
Q

Denosumab

Target/clinical use

A

RANKL

Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegrin)

Denosumab affects osteoclasts

19
Q

Digoxin immune Fab

Target/clinical use

A

Digoxin

Antidote for digoxin toxicity

20
Q

Omalizumab

Target/clinical use

A

IgE

Allergic asthma; prevents IgE binding to FcεRI

21
Q

Palivizumab

Target/clinical use

A

RSV F protein

RSV prophylaxis for high-risk infants

PaliVIzumab—VIrus

First Aid Step 1 Rapid Review (8 decks)

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