Paeds: Haematology

Question 1

Peak incidence of ALL?

Answer 1

2-5 years

Question 2

3 year old boy. Lethargy and pallor. Frequent or severe infections. Easy bruising, petechiae. Bone pain, splenomegaly. Most likely diagnosis?

Answer 2

ALL

/////////////////////////////// Bone marrow failure with organ infiltration. Peak incidence is 2-5 years. 80% of childhood malignancies.

Question 3

A 6-year-old girl presents with her mother who notices that her daughter often gets out of breath when climbing the stairs at home. She explains that she has been developing well through her childhood but is concerned as she is unable to keep up with her friends. On examination, small multiple bruises, of varying ages are seen on both her lower legs. She is afebrile and otherwise fit and well. Cardiac examination reveals a soft systolic murmur heard on the left sternal edge. Examination of her abdomen reveals a palpable mass in the left and right hypochondriac regions.

Which of the following is the most likely diagnosis?

Answer 3

ALL

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Aplastic anaemia would be same pres but without abdomen masses (ie organ infiltration)