paeds Flashcards
how might cmpa present?
vomiting
diarrhoea with blood
eczema
how do you test for lactose intolerance?
lactose hydrogen test
what are histological findings of coeliac disease?
jejunum is sampled
villous atrophy
crypt hyperplasia
t cell reaction! type 4!!!!
what isnt absorbed in coeliac disease?
iron
folate
b12
causes of pathological jaundice?
haemolytic
sepsis
what are the haemolytic causes of jaundice
rhesus incompatibility ABO incompatibiluty spherocytosis G6PD pyruvate kinase
what are the torch infections
toxoplasmosis others - syphilis rubella cmv herpes hepatits
is haemolytic jaundice conjugated?
no
criggler najjar
glucoronyl transferase deficient
what is galactosaemia
deficiency of galactose breakdown enzyme
cataracts and speech deficit and ataxia
remove dairy from mum and child
and continue breastfeeding
what is a coombs test used for?
check for ABO haemolysis
checks for antibodies on surface of RBCs
what investigations would yo do for neonatal jaundice?
coombs
bilirubin
FBC - anaemia. haemolysis
blood film - g6pd, spherocytosis
blood typing of mum and baby
how do you manage haemolytic disease of newborn?
phototherapy and check the threshold for the phototherapy and the plasma exchange transfusions
if phototherapy doesnt work what do you give?
ivig
exchange transfusion
how often is bilirubin monitored?
every 4-6 hours after phototherapy
when to stop phototherapy?
when bilirubin is 50 micromol/L below threshold
what is kernicterus?
deposition of unconjugated bilirubin in basal ganglia and brainstem nuclei
how does kernicterus present?
increased muscle tone
seizures
coma
death
complications of kernicterus?
choreoathetoid cerebral palsy
learning difficulties
sensorineural deafness
how does g6pd present?
neonatal jaunduce triggered by infections
intravascular haemolysis
splenomegaly
gallstones
how is g6pd diagnose?
g6pd enzyme assay
blood film: heinz bodies
bite and blister cells
what does bite and blister cells mean?
g6pd
what does heinz bodies indicate?
g6pd
what antibiotics are contraindicated in g6pd?
ciprofloxacin
sulphonamides (all sulphs)
antimalarials