Paeds Flashcards
what will you find in bacterial infected LP?
neutrophils, high opening pressure, high protein, low glucose
what will you find in viral infected LP?
lymphocytes, high opening pressure, normal glucose
name the most common bacterial commensal
N.meningitidis-even more common in smokers
what organisms are most likely to cause meningitis in different age groups?
Under 3m (neonates)-group b strep, listeria, e coli
3m-5y-h influenzae
5+-n meningitidis and strep pneumoniae
what would you give to the 14 year old sister of a young boy with meningitis?
ciprofloxacin
rifampicin is CI in pregnant and taking COCP
viral causes of meningitis?
HSV
enteroviruses
what are the symptoms of septic arthritis in a child?
acutely unwell
pseudoparesis
acutely tender erythematous joint
just limp or referred knee pain
management of child with suspected septic arthritis?
septic screen USS-effusion XR-any trauma aspiration and culture antibiotics initial short lived immobilisation
what presents in a similar way to septic arthritis?
transient synovitis it is more acute however and will resolve spontaneously. Pain is less severe, child is otherwise well
what is irritable hip?
acute transient synovitis
what do you see Nikolivsky’s sign with?
scalded skin syndrome, where the skin separates on touch
how might a child with hypoglycaemia present?
abdo pain irritability dizzy faint hunger seizure
what electrolyte disturbance may complicate hypoglycaemia and what are the signs of this?
hypokalaemia-shown by generalised muscle weakness
ST depression, t wave sagging
what are the dangers of infusing too quickly?
cerebral oedema-especially if salt and sugar are low
central pontine myelinolysis
what do steroids do to blood sugar levels?
increase them
how many compressions in a child?
5 breaths then 15 to 2, adrenaline every 3-5 mins
how is puberty triggered?
from 8yo-pulses of GnRH are started
what is the sequence of events in female puberty?
thelarche
adrenarce (hair growth, growth spurt, acne)
menarche
what is allopurinol used for in ALL?
tumour lysis syndrome prevention, high potassium, phosphate and lactic acidosis
acidotic symptoms
N&V stomach cramps hyperventilation chest pain/palpitations weakness
alkalosis symptoms
confusion seizures tetany abnormal sensations arrythmia
what are aplastic crises in sickle cell disease caused by?
parvovirus b19- treat with hydration and o2
give 2 enzymopathies which will lead to non spherocytic haemolytic anaemia
glucose 6 phosphate dehydrogenase deficiency
pyruvate kinase deficiency
what is a diagnostic feature of beta thalassaemia on HPLC?
high HbA2 (2 alpha, 2 delta)
what should you consider in an anaemic child who is not responding to treatment?
alpha thalassaemia trait-no treatment
what is vWF?
the carrier protein for VIII and it sticks platelets to damaged endothelial wall
what is the underlying pathology of haemolytic disease of the newborn?
isoimmune-rhesus disease, need to prevent or give transfusions
how is haemophilia transmitted?
x linked
what could cause thrombocytopenia in children?
ITP, SLE, HUS (shigella), DIC, scurvy; impaired production from Fanconi, aplastic anaemia
what are kocher’s criteria?
fever>38.5
ESR>40 in first hour
WCC>12
unable to weight bear
when is internal rotation painful?
in septic arthritis, kept abducted, externally rotated and flexed and in Perthe’s internal rotation will lead to guarding or spasm
what are the risk factors for developmental dysplasia of the hip?
female, breech, oligohydramnios, C section, first child, club foot and other deformaties
what are the most common viruses in bronchiolitis?
respiratory syncitial virus in most, but also influenza, papa and adneno, rhino
what does smoking in pregnancy increase risk of?
asthma, IUGR, prematurity, miscarriage, SIDS, cleft lip
febrile, toxic infant, irritable with nappy changing with restricted joint range-what is the diagnosis and how is the hip likely to be arranged?
septic arthritis
abducted, externally rotated and flexed
sudden limp in otherwise well child
transient synovitis-child feels well but can also have fever, irritablility. they’ll have no pain at rest
fever, erythematous rash, red eyes, irrritability, oral mucositis, erythema of hands and feet
Kawasaki disease
loss of ROM, pain, stiffness and restriction
not so much swelling so JIA, in systemic will also have fever and serositis
points of a baby check?
heart-listen eyes-red reflex: retinoblastoma or cataracts hips-O+B testicles-descended, check female (check anus head circumference and fontanelles cleft feel tummy check back stretch legs-talipes equinovarus)
what are the symptoms of Steven’s Johnson?
cough, fever, conjunctivitis, rash on skin, burning sensation
what drugs can cause Steven’s Johnson?
allopurinol, carbemazepine, CMV
what will be raised in Kawasaki disease?
ESR, CRP, WCC, neutrophils, plts
what organ infiltration can occur in ALL other than hepatosplenomegaly?
CNS>headaches and seizures
testicular enlargement
what kind of lymphoma is more common in children?
non Hodgkins
commonest kind of brain tumour in children?
astrocytoma
what finding will you get when investigating a child with neuroblastoma
increased catecholamines
what happens in Langerhan’s cell histiocytosis?
bone lesions>fracture
DI
what is Reye’s syndrome?
asso with aspirin and URTI
non inflammatory encephalopathy and fatty degeneration of the liver. Only supportive management
what is Cushing’s triad?
bradycardia, systolic hypertension and irregular tachypnoea
what does a child with homocysteinuria need?
B6 supplements
in what disease can you not make dopamine or catecholamines
phenylketonuria because can’t make tyrosine
what does mineralcorticoid do?
retains bicarb and sodium and flushes out potassium
what is the peak height velocity?
girls-stage 3 breast development
boys-12-14mL
most likely meningitis bugs in neonates?
E coli
L. monocytogenes
GBS
most likely meningitis bugs in 1m-6y?
NHS
most likely meningitis bugs 6+
N and S
what facial defects do you get with Down’s syndrome?
flattened nose
macroglossia
shortened neck
epicanthic folds
what are the 3 types of cerebral palsy?
athetoid
spastic
ataxic
what long term problems are associated with Down’s syndrome
learning difficulties
congenital heart disease
early Alzheimer’s
what is achondroplasia?
AD bone disorder- disproportionately small limbs, frontal bossing, large skull
may also have hydrocephalus
what is Marfan’s?
AD disorder of connective tissue tall long thin digits hyperextensible joints high arched palate myopia asso chest deformity and scoliosis, incompetent aortic root with valvular incompetence, mitral prolapse and regurgitation and aortic aneurysms echo monitoring is needed
define failure to thrive
significant interruption of growth compared to other children of a similar age, sex and height, crossing 2 centiles on a growth chart
what do stridor and wheeze indicate?
stridor-upper airway obstruction
wheeze-decreased diameter in the lower airways from secretions
key features of measles
maculopapular behind ears and on face then trunk and extremeties
koplick spots
what do koplick spots look like?
buccal mucosa, opposite second molar, red spots with white or blue speck in the middle
causes of non blanching rash
thrombocytopenia
bacteraemia
enteroviruses and influenza
HSP
what do you need to investigate in someone with HSP?
BP
U&Es for dehydration and renal function
urinalysis
how do you manage impetigo?
fusidic acid topically, if don’t respond then oral fluclox
what bacteria commonly case impetigo
strep pyogenes
staph aureus
what are the common causes of encephalitis in children?
delayed swelling following response to an antigen eg respiratory viruses and enteroviruses
direct invasion of the brain by a neurotoxic virus like HSV-usually treated with IV aciclovir because of this
what are the 3 features of toxic shock syndrome caused by S. aureus?
fever>39
hypotension
diffuse erythematous macular rash
where might periorbital infection spread from and to?
from otitis media or dental abscess
to orbit and then on to meningies
what kind of rash do you get with rheumatic fever
erythema marginatum
how long does chickenpox last for?
7 days
what can enteroviruses cause in children?
encephalitis
hand foot and mouth
meningitis
myocarditis
why does a barking cough occur in croup?
immobilisation of the vocal cords
what is included in airway remodelling
more goblet cells
more muscle mass in wall of airways
onset of abscence seizures
4-12
what is the most common cause of respiratory distress in term infants?
transient tachypnoea of newborn- more common if CS, usually settles after a day and infection needs to be ruled out
what kind of cells produce surfactant?
type II pneumocytes
what is given as the prophylxis of pertussis?
macrolides
erythromycin for preggers
when is viral episodic wheeze most common
4-6 yo
what is osgood schlatter’s
osteochondritis of the patellar tendon
how do you improve meal refusal?
don't force feed more regular meals more suitable meals smaller portions less distractions less snacking
what are the features of anorexia nervosa?
self induced weight loss to 85% of original weight or becoming under 17.5 distorted body image fear of gaining weight endocrine disorder delay in puberty
what are the features of bulimia
persistent preoccupation with eating and irresistible craving for food
counteracting with purging or starving
dread of gaining weight
physical features of anorexia
cold peripheries bradycardia amenorrhoea lanugo hair ankle oedema
how is Bell’s palsy treated
10 d pred
what is the most common kind of strasbismus?
non paralytic-concomitant-imabalance in extraocular muscles
what is strasbismus asso with
LDS, Down’s, CP, Edward’s