PAEDS 2: Neonates and Development Flashcards

1
Q

What is the criteria for the APGAR score?

A

Appearance (0 = blue/pale, 1=blue extremities, 2= no cyanosis)

Pulse rate (0 = <60, 1 = 60-100, 2 = >100)

Grimace (0 = no response, 1 = aggressive stimulation needed for cry, 2 = cries on stimulation)

Activity (0 = absent/floppy, 1 = some flexion, 2 = flexes + resists extension)

Respiratory effort (0 = absent, 1 = weak/gasping, 2 = strong cry)

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2
Q

How often is APGAR done and what are the threshold levels?

A

Done at 1 and 5 minutes post-birth and continued if score under 7.

Totals:
7+ = normal
4-6 = low
3 or less = critically low

(resuscitation should begin before 1 minute score if critically unwell)

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3
Q

Outline neonatal life support for a term baby

A
  1. dry/wrap, stimulate, keep warm, delay cord clamping if possible
  2. assess APGAR
  3. ensure open airway (if preterm consider CPAP)
  4. if gasping/not breathing give 5 inflations in air, apply PEEP, SpO2 and ECG if possible
  5. reassess
  6. if chest not moving, check positions, 2 person support, consider sunction and laryngeal mask, repeat inflation breaths
  7. reassess
  8. if HR not detectable or <60bpm after 30 secs of ventilation do 3:1 chest compression to ventilation, increase O2 to 100% and consider intubation
  9. reassess and if still no recovery gain vascular access and administer drugs
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4
Q

Outline neonatal life support for a preterm baby <32 weeks

A

place undried in plastic wrap + radiant heat

inspired oxygen of 21-30% if 28-31 weeks gestation or 30% if <28 weeks gestation

if giving inflations start with 25cm H2O

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5
Q

How do you assess neonatal cyanosis (blue baby)?

A

Hyperoxia test - give 100% O2 for 10 mins then do ABG and assess PaO2

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6
Q

What does a PaO2 >15kPa on the hyperoxia test suggest?

A

Respiratory cause of neonatal cyanosis e.g. NRDS, transient tachypnoea, meconium aspiration

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7
Q

What does a PaO2 <15kPa on the hyperoxia test suggest?

A

Cardiac cause of neonatal cyanosis e.g. tetralogy of fallot, transposition of great arteries, tricuspid atresia, ebstein’s anomaly

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8
Q

What would imaging and treatment be for NRDS?

A

CXR = ground-glass lung apperance
RF = prematurity
Mx = surfactant therapy

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9
Q

What would imaging and treatment be for transient tachypnoea of the newborn?

A

CXR = fluid on horizontal fissure
Mx = resolves spontaneously

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10
Q

What would imaging and treatment be for meconium aspiration?

A

CXR = lung overinflation, patches of collapse and consolidation
RF = macroscomia
Mx = IV Abx

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11
Q

What would investigations show for tetralogy of fallot?

A

CXR = boot shaped heart
Cyanosis in days, on exertion (tet spells)
ESM

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12
Q

What would investigations show for transposition of great arteries?

A

CXR = round heart
Cyanosis in hours
Loud S2, no murmur

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13
Q

What would investigations show for tricuspid atresia?

A

CXR = prominent aortic root
Cyanosis upon minutes
ESM

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14
Q

How are cardiac causes of neonatal cyanosis managed?

A

Prostaglandin infusion + delayed surgery

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15
Q

What are the steps of NIPE (newborn infant physical examination)?

A
  1. General measurements (height, weight, head circumference, abdominal circumference etc.)
  2. General inspection (tone, look at spine, moles, skin abnormalities, looking at feet and hands etc., primitive reflexes)
  3. Eyes (red reflex on both eyes, absent red light reflex = sign of congenital cataracts)
  4. Heart (murmurs, pulses esp. femoral, if absent or asymmetrical may indicate narrowing of aorta)
  5. Hips (DDH tests)
  6. External genitalia
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16
Q

What primitive reflexes are tested in the NIPE?

A

Placing reflex - when dorsum of foot touches surface, steps onto it (lasts 3/12)

Palmar grasp - lasts 3/12

Rooting reflex - turns head if touched near mouth
Sucking reflex - sucks nipple or teat placed in mouth

Asymmetric tonic neck reflex (ATNR) - fencing posture on turning head to one side (lasts 5/12)

Moro reflex - symmetrical abduction and extension followed by flexion and adduction of arms on sudden head extension (lasts 3/12)

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17
Q

What does an absence of the red light reflex in a newborn signify?

A

Congenital cataracts (may be secondary to TORCH infection, genetic syndromes e.g LHON etc.)

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18
Q

How can neonatal murmurs be classified?

A

Cyanotic
Non-cyanotic
Innocent

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19
Q

How does a cyanotic murmur present?

A

Right to left shunt (more life threatening than left to right)
ESM (except for TGA)

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20
Q

What congenital heart defects cause non-cyanotic murmurs?

A

1) Left to right shunts: PDA, ASD, VSD

2) Outflow obstructions: valve stenosis, coarctation of aorta

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21
Q

How does a PDA present?

A

Gibson murmur - continuous machine like murmur

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22
Q

How does an ASD present?

A

ESM + fixed S2 splitting

Primary = foramen ovale
Secondary = defect of atrial septum

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23
Q

How does VSD present?

A

If large = soft PSM + apical MDM + loud P2

If small = loud PSM + quiet P2

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24
Q

How does valve stenosis present?

A

ESM + ejection click + quiet A2/P2

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25
How does coarctation of aorta present?
ESM (radiates to scapula/back) + pulse asymmetry/absence
26
What are features of innocent murmurs?
soft, asymptomatic, systolic, LSE, normal HS
27
How is a cyanotic heart murmur managed?
Prostaglandin infusion (keep PDA open) + delayed surgery
28
How is a PDA managed?
Indomethacin - coil closure/ligation at 1yo
29
How is an ASD managed?
Endovascular occlusive device or surgical repair at 3yo
30
How is a VSD managed?
if large = CDC = calories, diuretics (captopril); surgery at 3-6mths if small = self limiting
31
How is a valve stenosis managed?
Balloon angioplasty
32
How is a coarctation of aorta managed?
prostaglandin infusion -> surgical repair/balloon angioplasty
33
What tests are used for assessing whether there's DDH in a neonate?
Barlow's test = promoting femoral head dislocation by applying posterior force on knee and adducting baby's legs Ortolani's test = reducing hip into place by applying anterior force on knee and abducting baby's legs
34
What is important to assess when checking external genitalia of a newborn?
Hypospadias (urethral opening in wrong place), undescended testes, ambiguous genitalia etc.
35
What are differentials for a "floppy baby"?
Down's syndrome = characteristic facies, trisomy 21 Hypothyroidism = abnormal TFTs, dry skin, constipation, iodine deficiency in pregnancy Hypoglycaemia = jittery, seizures, diabetic mother - SGA or LGA baby, BM <1.4mmol/L HIE/intracranial bleed = hx prolonged/traumatic delivery, intraventricular haemorrhage on USS
36
What are the mechanisms behind Down's syndrome?
Trisomy 21 caused by: - meiotic non-disjunction (MOST COMMON) - robertsonian translocation - mosaicism
37
What are features of Down's syndrome by body system?
FACE = epicanthic folds, up-slanting eyelids, flat profile HEART = endocardial cushion defects (AVSD, ASD) STOMACH = Hirschsprung's, duodenal atresia EARS = low set small ears, recurrent OME BRAIN = dementia, learning difficulties, epilepsy HANDS & FEET = clindactyly, single palmar crease, wide sandal gap
38
What investigations would you do to find potential complications of Down's syndrome?
Echo - for AVSD/VSD USS abdomen - for Hirschsprung's/duodenal atresia AXR - duodenal atresia shows double bubble sign (stomach + duodenal bubble) Barium enema - hirschsprung's has no fluid level (whereas meconium ileus does)
39
What is Turner's syndrome?
45XO
40
What are some features of Turner's syndrome?
EXTERNALLY = short stature, webbing of neck, broad chest, widely spaced nipples, pigmented naevi, peripheral lymphoedema, cubitus valgus INTERNALLY = coarctation of aorta, bicuspid aortic valve, streak ovaries, infertility, amenorrhoea
41
What investigations should be done for neonatal jaundice?
Bedside = transcutaneous BR, urine sample Bloods = total serum BR, direct Coombs test, direct serum BR, FBC, reticulocyte count, blood smear, LFTs, blood cultures, viral screen Imaging = abdo USS, percutaneous liver biopsy
42
What does it mean if there is neonatal jaundice and there is a Coombs +ve test?
Iso-immune reaction i.e. ABO or Rh incompatibility
43
What are causes of neonatal jaundice w/unconjugated bilirubin?
Physiological OR Pathological (haemolytic or non-haemolytic)
44
What are physiological causes of neonatal jaundice?
Prematurity Breastfeeding jaundice (insufficient feeding leads to high bilirubin- PC within 1w) Breastmilk jaundice (breast milk itself is causing high bilirubin, PC >10d)
45
What are non-haemolytic causes of neonatal jaundice?
Sepsis Cephalohaematoma Hypothyroidism Gilbert's Crigler-Najaar Ix = septic screen, TFTs, PC liver biopsy
46
What are signs of haemolytic neonatal jaundice?
high LDH, high reticulocytes, abnormal smear, low Hb
47
What is classed as pathological jaundice in a neonate?
presenting in first 24h or has lasted beyond 1w
48
What are intrinsic/coombs -ve causes of haemolytic neonatal jaundice?
Enzyme deficiencies Membrane defect Haemoglobinopathies
49
What are extrinsic/coombs +ve causes of haemolytic neonatal jaundice?
ABO or Rh incompatibility
50
What is important about conjugated bilirubin when investigating neonatal jaundice?
It's always pathological
51
What are intrahepatic causes of conjugated bilirubin neonatal jaundice and what investigations would you see?
IX: Deranged LFTs Liver dysfunction markers CAUSES: Infections Drugs Genetic/metabolic syndromes
52
What are extrahepatic causes of conjugated bilirubin neonatal jaundice and what investigations would you do?
IX: Abdo USS CAUSES: Biliary atresia (MOST WORRIED ABOUT THIS ONE - needs surgery) Choledochal cysts CF Galactosaemia
53
What are some differentiators between congenital causes of neonatal jaundice?
uBR = Gilbert's syndrome (otherwise normal), Crigler-Najaar (hypotonia, ocular palsy) cBR = Dubin-Johnson syndrome (black liver on biopsy), Rotor syndrome (normal LFTs, normal colour on biopsy), Hepatocellular insult
54
How would you manage physiological neonatal jaundice?
Reassurance Feeding optimisation Phototherapy
55
How would you manage an uBR neonatal jaundice?
Phototherapy Exchange transfusion (IMPORTANT TO TREAT DUE TO RISK OF KERNICTERUS)
56
How would you manage a cBR neonatal jaundice?
Treat underlying cause Kasai procedure (for biliary atresia)
57
What are the developmental milestone domains?
Gross motor Vision and fine motor Hearing, speech and language Social, emotional and behavioural
58
What are red flags for gross motor development?
6mths = head control 9mths = sits unsupported 12mths = stands w/support 18mths = walks independently Hand preference before 1yo
59
What are red flags for vision and fine motor development?
3mths = fixes and follows 6mths = reaches for objects 9mths = transfers 12mths = pincer grip
60
What are red flags for hearing, speech and language development?
6mths = babble 9mths = consonant babble 18mths = 6 words 2yo = joins words 2.5 yo = 3-word sentences
61
What are red flags for social, emotional and behavioural development?
6wks = smiles 9mths = fear of strangers 18mths = feeds self/spoon 2-2.5yo = symbolic play 3-3.5yo = interactive play
62
What are some causes of a gross motor delay? (how could you categorise differentials?)
Physical causes i.e. muscle/power abnormalities Developmental causes i.e. maturational delay
63
What are some physical causes of gross motor delay?
Hypertonic - Cerebral palsy Hypotonic - Down's syndrome, Hypothyroidism Normal tone - Muscle dystrophies, Duchenne's, Becker's
64
What are some developmental causes of gross motor delay?
Later walkers Neglect Learning disabilities
65
What is a classic sign of Duchenne's muscular dystrophy?
Gower's sign - using hands to stand from sitting
66
What investigations and management would you do for gross motor delay?
Bedside = full developmental assessment Bloods = creatine kinase, autoimmune screen, genetic screen Imaging = CT head Specialised tests = muscle biopsy, NCS, EMG Mx = OP, OT, genetic counselling
67
What are some physical problems that cause speech delay?
Articulation = cleft lip/palate Conductive hearing impairment = glue ear Sensorineural hearing impairment = TORCH infection, meningitis, iatrogenic, SOL
68
What are some developmental problems that cause speech delay?
Maturational delay = late talkers, neglect, learning disabilities Social communication = ASD
69
What investigations would you do for speech delay?
Bedside = full developmental assessment, otoscopy
70
What hearing tests are done during newborn screening?
AOEA (automated otoacoustic emission assessment) if this is abnormal then do AABR (automated auditory brainstem response)
71
What hearing test is done for <3yo?
VRA (visual reinforced audiometry)
72
What hearing test is done for >3yo?
PTA (pure tone audiometry)
73
How is hearing impairment managed?
Conductive/glue ear = Grommet (drains fluid) Sensorineural = hearing aids
74
What are physiological causes of failure to thrive?
Familial short stature = following growth centile within predicted parental height range, normal bone age Consitutional delay of growth = delayed bone age
75
What are pathological causes of failure to thrive and their features?
Genetic syndromes (dysmorphic features, disproportion) = Down's, Turner's, Noonan's, Achondroplasias Nutrition and general health (falling across centiles, weight < height, delayed bone age) = malabsorption, chronic illness, psychosocial neglect Endocrine (falling across centiles, weight > height, delayed bone age) = hypothyroidism, GH deficiency, steroid excess
76
What investigations would you do for failure to thrive presentation where a child is falling across centiles?
Is dependent on age Bedside = stool sample (faecal calprotectin) Bloods = FBC, LFTs, U&Es, TFTs, anti-TTG, karyotype/microarray, IGF-1, bone profile, CRP/ESR Imaging = XR non dominant hand