PAEDS 1: Respiratory and Childhood Infections Flashcards
What are causes of neonatal tachypnoea?
- transient tachypnoea of the new-born
- respiratory distress syndrome
- sepsis
What are key features of transient tachypnoea of the new-born?
- within 4-6 hours of delivery
- C-section, fast delivery
- no O2 requirement
What are key features of respiratory distress syndrome?
- prematurity
- O2 requirement
- persistent
What are key features of sepsis?
- RF: maternal temp, PROM, GBS
- other abnormal observations
- persists > 4 hrs
What are risk factors for transient tachypnoea of the newborn?
- <39 weeks (prematurity)
- gestational diabetes
- maternal asthma
- male
- SGA, or LGA
- c-section
Sx of transient tachypnoea of the newborn?
tachypnoea (RR > 60), grunting, nasal flaring recessions, respiratory deterioration
Rx of transient tachypnoea of the newborn?
- Saturations - pre and post ductal
- examination +/- blood gas
- initial obs and monitoring if TTN seems likely
- persistent - septic screen, CXR
- O2 requirement - NICU admission
- consider - congenital anomalies, cardiac causes, inborn errors
What is the aetiology of respiratory distress syndrome?
Surfactant production starts at ~20 weeks - sufficient levels reached by 35-36wks.
Surfactant deficiency leads to increased surface tension of small alveoli - atelectasis - collapse
RFs of respiratory distress syndrome?
Prematurity, GDM, multiple gestation, birth asphyxia
Signs and Sx of Respiratory Distress Syndrome?
tachypnoea (RR > 60), cyanosis, within mins of delivery
uniformly decreased air entry, poor peripheral perfusion, work of breathing: grunting, recessions, accessory muscles
Rx of Respiratory Distress Syndrome?
Antenatally - steroids
Neonate - apply PEEP w/mask +/- O2, whilst monitoring sats
Examine HS, lung fields, assess prematurity if unknown gestation
Give surfactant via LISA or endotracheal tube
CXR + blood gas
Septic screen
Assess level of resp support required - high flow/CPAP/invasive ventilation
Consider: pneumothoraces, response to O2 therapy
What is a classical CXR finding of Respiratory Distress Syndrome?
“diffuse ground glass appearance”
What is bronchopulmonary dysplasia?
supplemental oxygen or respiratory support required >36 weeks corrected gestation
RFs for bronchopulmonary dysplasia?
Lower gestational age, lower birthweight, SGA, invasive ventilation <24hrs, clinical sepsis, CPR required
What are complications of bronchopulmonary dysplasia?
systemic HTN, pulmonary HTN, poor neurodevelopmental outcome, left ventricular hypertrophy
What is early intervention for bronchopulmonary dysplasia?
supplemental O2 (target sats >90% after first 10mins of life), NIV where able e.g. CPAP, early surfactant use, early caffeine initiation (<3 days), volume targeted ventilation, low dose dexamethasone
What is established management for bronchopulmonary dysplasia?
diuretic therapy, tracheostomy consideration, home oxygen support, RSV immunisation
What is the prognosis of bronchopulmonary dysplasia?
high rates of readmission in 1st year
reactive airway disease e.g. bronchiolitis, wheeze, asthma
may need home O2 for a period
impact on development and growth
What are some imaging changes you might see for bronchopulmonary dysplasia?
CXR - reticular markings
CT - bronchial wall thickening
What are some causes of tachypnoea/cough in a child?
- Pneumonia
- CF
- TB
What are key features of pneumonia in a child?
Acute cough, fever >39C, cyanosis, raised RR, increased WOB, focal crackles, sats <95%, absent breath sounds
What is the diagnostic criteria of bacterial pneumonia?
consider where: persistent fever >38.5 with chest recessions and raised RR
What are complications of pneumonia?
empyema, lung abscess, atypical pathogen
What pathogens cause pneumonia in neonates?
GBS, Klebsiella, E. Coli, Listeria
What pathogens cause pneumonia in children <2yrs?
Viruses - RSV, influenza
What pathogens cause pneumonia in children 2-5yrs?
S. pneumoniae, H. influenzae
What pathogens cause pneumonia in children >5yrs?
Mycoplasma pneumoniae, S. pneumoniae
Rx of pneumonia in children?
- Assess severity to decide if admission needed. Red flags = sats <92, not responding to Abx, absent breath sounds, increasing WOB
- community management = anti-pyretics, fluids, identifying deterioration
- hospital management = O2 to maintain sats >92%, IVF as required (monitor U&Es)
- Follow up radiography - only in those w/round pneumonia, complications or persistent sx
When are antibiotics not used in pneumonia?
if <2 years w/mild sx (but review if persistent)
When are antibiotics indicated?
Oral if tolerated, IV if unable to tolerate/absorb, septicaemia, complicated pneumonia, Abx given if clear clinical diagnosis of pneumonia
What is the 1st line antibiotic for childhood pneumonia if non-severe sx?
amoxicillin (clarithromycin if pen allergic)
What is the 1st line antibiotic for childhood pneumonia if severe sx?
co-amoxiclav + clarithromycin
What is Cystic Fibrosis?
an inherited disease caused by mutations in a gene called the cystic fibrosis transmembrane conductance regulator (CFTR)
How is CF diagnosed?
Infant screening - immunoreactive trypsin test
Sweat test
Genetic testing (AR)
How does CF present?
Meconium ileus, faltering growth, recurrent/chronic resp disease, chronic sinus disease, acute/chronic pancreatitis
What are complications of CF?
malnutrition (fat soluble vitamin deficiences - ADEK), infertility, CF-related diabetes, reduced bone density
Rx of CF?
Support and education
MDT - specialist nurse, physio, dietitian, pharmacists, psychologist
Antibiotics - long term, IV courses, nebs, prophylaxis vs treatment
Physio - twice daily, extensive, airway clearance
Mucoreactive agents - DNAase, hypertonic saline
Monitor colonisation - eradication where needed
Enzyme supplements
Gene therapy e.g. Kaftrio (F508del mutation)
What is TB?
Infection caused by mycobacterium tuberculosis
What are RFs for TB?
born outside UK, high prevalence areas, <5yo, close contacts w/active TB, co-morbidities, e.g. HIV, DM, ESRF, underserved groups
Sx of TB?
cough, fever, night sweats, malaise
lymphadenopathy
faltering growth, fatigue, persistent fever
meningitis
children typically present w/non-specific signs and usually can’t expectorate <5yrs
Ix for TB?
CXR, deep cough sputum, gastric washings, induced sputum, rapid testing (NAAT), additional scans/tests if extra-pulmonary sx
Exposure testing:
- Mantoux test (tuberculin skin test)
- IGRA (blood test detecting response of WBC to TB antigens)
How is TB managed in children?
Active TB should be managed by a TB specialist
Active w/o CNS involvement = RIFE (+pyridoxine) 2/12, then just RI for 4/12
Active w/CNS = RIFE (+pyridoxine) 2/12, then just RI for 10/12
Consider drug susceptibility testing, fixed dose combo, daily directly observed therapy for MDR-TB
Summarise rhinitis/common cold?
Causes = viral (rhinoviruses, RSV, coronaviruses, parainfluenzae, influenza, human meta-pneumovirus)
Complications = predisposes to bacterial sinus and ear infections
Mx = supportive care, reassurance, education, safety netting
Summarise key features of tonsilitis?
Definition = palatine tonsil inflammation (tonsil grading system 0-IV)
Cause = adenovirus, EBV, group A strep
Sx = 5-7 days painful swallowing, fever, snoring, halitosis
Signs = red inflamed tonsils, white exudate spots, cervical lymphadenopathy
Mx = antibiotics if likely bacterial (Centor 3+)