Paediatrics - Growth, puberty, endocrine (2) Flashcards
What is the definition of short stature?
Height below the second centile (ie. two standard deviations below the mean)
Height velocity is a sensitive indicator of what?
Growth failure
How is height velocity calculated?
2 measurements at least 6 months but preferably a year apart = cm/year
A height velocity of consistently below what centile is abnormal?
25th
How is a child’s genetic target centile for height calculated?
Mean of father and mothers height + 7cm for boy and -7cm for girl.
The 9th-91st centile range of this estimate is given by +- 10cm for boys and +-8.5cm for girls
What percentage of children born with severe IUGR remain short?
33%
Give 6 causes of short stature in children
- Familial short stature or constitutional delay of growth and puberty
- IUGR
- Endocrine
- Nutritional/ chronic illness
- Psychosocial deprivation
- Chromosomal disorder/syndromes
Give 3 endocrine causes of short stature in children
- Hypothyroidism (autoimmune thyroiditis during childhood)
- Growth hormone deficiency (can be secondary to hypopituitarism)
- Corticosteroid excess (Cushing’s syndrome)
Where is IGF-1 produced?
Growth plate and in the liver
Give two causes of growth hormone deficiency
- Craniopharyngioma
2. Laron syndrome
How does a craniopharyngioma often present?
Bitemporal hemianopia
What is Laron syndrome?
Defective growth hormone receptors = high levels of growth hormone and low levels of IGF-1.
Give 3 examples of chronic illnesses that may result in short stature?
- Coeliac disease
- Crohn’s disease
- Chronic renal failure
Give 4 examples of syndromes in which short-stature is seen.
- Down’s syndrome
- Turner’s syndrome
- Noonan syndrome
- Russell-Silver syndrome
Deficiency of which gene on the X chromosome is thought to be linked to short stature and skeletal abnormality
SHOX
How is growth hormone deficiency treated?
Biosynthetic growth hormone, given by subcutaneous injection daily
Give two examples of syndromes or scenarios in which administering daily growth hormone is a treatment.
- Prader-Willi syndrome - improves muscle strength and body composition
- Turner’s syndrome -
- Chronic renal failure
- SHOX deficiency
- IUGR
How do you calculate the ideal weight of children based upon their age?
(age+4) x 2 = weight (kg)
Give the type of fluid that is typically prescribed to older children
0.9%NaCl + 5% glucose +-KCl
Give the fluid requirements per kg for the first four days of life (per day)
Day 1 = 60ml/kg/day
Day 2 = 90ml/kg/day
Day 3 = 120ml/kg/day
Day 4 = 150ml/kg/day
Give the electrolyte requirements per day of sodium, potassium and calcium in neonates
Na = 3mmol/kg/day K = 2mmol/kg/day Ca = 1mmol/kg/day
Give maintenance fluids per day
First 10 kg = 100ml/kg/day
Second 10 kg = 50ml/kg/day
Over 20kg = 20ml/kg/day
Give hourly maintenance fluids
First 10kg = 4ml/kg/hour
Second 10kg = 2ml/kg/hour
Over 20kg = 1ml/kg/hour
Give 5 signs of a dehydrated infant
- Depressed fontanelle
- Cap refill 2-3 s
- Alert/tired
- Reduced urine output
- Dry lips/mucous membranes