Paediatrics 3 Flashcards
1
Q
Which antigens are associated with Coeliac Disease?
A
- Class II HLA-DQ2 and -DQ8
2
Q
What is the pathophysiology behind Coeliac disease?
A
Heightened T- and B- lymphocyte responses to wheat gluten and other prolamines
3
Q
List some non-GI manifestations of Coeliac disease.
A
- Dermatitis herpetiformis
- Dental enamel defects
- Osteoporosis: Low bone mineral density
4
Q
Which antibodies are associated with Coeliac disease?
A
- Antigliadin
- Anti-endomysial
- Tissue transglutaminase
5
Q
What is the criteria for diagnosis of Coeliac disease in childhood?
A
- Characteristic histology (Marsh type III a - c)
- Positive serology
- Symptomatic response to gluten exclusion
- Resolution of antibodies
6
Q
List some risk factors for coeliac disease.
A
- Positive FHx
- Diabetics
- Short stature
- Down’s syndrome
- Thyroid disorders
- IgA deficiency
