Paediatrics Flashcards
What is the most common congenital heart defect?
Ventricular septal defect
Lithium use during pregnancy can cause what cardiac congenital malformation?
Ebstein’s anomaly
Where in the foetal heart is the foramen ovale located? What type of blood is passed through this foramen?
Between the right and left atrium; oxygenated
Where in the foetal heart is the ductus arteriosus located? What type of blood passes through this duct?
Between the pulmonary artery and aorta; oxygenated
The ductus arteriosus is kept open by what during foetal life?
Prostaglandins
The ductus venosus is located where in the foetus? What type of blood is shunted here?
Between the umbilical vein and inferior vena cava; oxygenated
Name the 2 cyanotic congenital heart defects
Transposition of the great arteries and Tetralogy of Fallot
What type of shunt does ventricular septal defect and atrial septal defect cause?
Left to right
Name the congenital heart malformation described:
Harsh pansystolic murmur heard best at the left lower sternal edge
VSD
Name the congenital heart malformation described:
Ejection systolic murmur heard best at upper left sternal edge with radiation to the back
Atrial septal defect
Name the congenital heart malformation described:
Continuous machine like murmur + collapsing pulse
Patent ductus arteriosus
Name the congenital heart malformation described:
Ventricular septal defect + overriding aorta + right ventricular hypertrophy + right outflow tract obstruction
Tetralogy of Fallot
How long after birth will transposition of the great arteries present compared to Tetralogy of Fallot?
TGA - first few hours
TOF - first 1-2 months
Coarctation of the aorta is most commonly associated with what genetic syndrome?
Turner’s syndrome - 45X
What cardiac malformation is most associated with Trisomy 21?
Atrio-ventricular septal defect
Supravalvular aortic stenosis is most commonly associated with genetic syndrome?
Williams syndrome
22q11 deletion (Di-George syndrome) is most associated with which congenital cardiac malformation?
Tetralogy of Fallot
Eisenmenger’s syndrome can result from lack of treatment of what cardiac congenital malformations?
ASVD, VSD, ASD, PDA
(Anything that causes a left to right shunt initially)
What type of shunt is seen in Eisenmenger’s syndrome?
Right to left
Name the syndrome:
VSD + cyanosis + polycythaemia + syncope
Eisenmenger’s syndrome
Name the presenting cardiac congenital malformation:
Prolonged crying + increasing cyanosis + knees to chest + poor feeding
Tetralogy of Fallot
(Tet spells)
Which medication can be given to encourage closure of a patent ductus arteriosus?
Indomethacin, ibuprofen
(Prostaglandin inhibitors)
Pulmonary hypertension and congestion is a feature of which cardiac congenital malformations?
Any that cause left to right shunt - ASVD, VSD, ASD, PDA
Patients with transposition of the great vessels should be given what until surgery can be performed?
Prostaglandin infusion to keep ductus arteriosus open
Name the cardiac congenital malformation:
Weak femoral pulse + harsh systolic murmur at left sternal edge with radiation to the back
Coarctation of the aorta
Chronic coarctation of the aorta can lead to what clinical sign?
Radio-femoral delay
Congenital heart diseases can cause which metabolic disturbance on blood gas in neonates?
Metabolic acidosis
Name the murmur:
Ejection systolic heard at upper right sternal border + radiation to carotids
Aortic stenosis
Name the murmur:
Ejection systolic heard at upper left sternal border + radiation to the back
Pulmonary stenosis
Name the murmur:
Varies with posture + no thrill + asymptomatic
Innocent murmur
Noonan’s syndrome is most commonly associated with which heart murmur?
Pulmonary stenosis
Developmental dysplasia of the hip can be elicited with what tests?
Barlow’s or Ortolani’s
Name the orthopaedic complaint:
Easily dislocation of the hip + positive Ortolani’s test + breech presentation at birth
DDH
Name the orthopaedic complaint:
Limp + limited movement of hip joint + xray findings of sclerotic epiphysis
Perthes disease
Name the orthopaedic complaint:
Displacement of femoral head on neck + obese child + altered gait
Slipped upper femoral epiphysis
Spasticity in cerebral palsy can be managed by what medications?
Baclofen or diazepam
Significant talipes can increase the risk of what other orthopaedic complaint in children?
DDH
For how many hours a day should scoliosis braces be worn?
23-24 hours a day
Name the orthopaedic complaint:
Pain and limited movement of the hip + low grade fever + bilateral effusion on USS
Transient synovitis
Name the orthopaedic complaint:
Morning stiffness + fatigue + 3 joints affected
Pauciarticular juvenile idiopathic arthritis
Which type of JIA is most commonly associated with uveitis?
Pauciarticular
Which type of JIA is most commonly associated with constitutional symptoms?
Polyarticular RF-ve
Name the orthopaedic complaint:
Arthritis symptoms + salmon pink erythematous rash + high CRP and ESR
Systemic onset JIA
A child with JIA has poor response to intra-articular steroids. What treatment should be initiated?
DMARDs - methotrexate SC injection
Name the presentation:
Arthritis + red eyes + headache
Uveitis
Name the orthopaedic complaint:
Fever + joint swelling + elevated CRP and WCC
Septic arthritis
How should a child with septic arthritis be managed?
Immediate referral, IV antibiotics, joint aspiration
The nephron receives how much of cardiac output?
25%
What is the GFR in a neonate?
20-30ml/min/1.73m^2
Frothy urine indicates the presence of what?
Protein in the urine
Name the renal complaint:
Facial swelling + normal light microscopy + proteinuria +++
Minimal change disease
What is the gold standard for diagnosing minimal change disease?
24 hour urine protein collection
What treatment should be given to this child:
Facial swelling + preceding viral URTI + normal BP
8 weeks of prednisolone
Steroid resistance in minimal change disease would indicate a change in diagnosis to what?
Focal segmented glomerulosclerosis
What should this child be treated with:
Steroid resistant minimal change disease
Cyclophosphamide or ciclosporin
Name the renal complaint:
Hypertension + 2 day history of URTI + frank haematuria
IgA nephropathy
What type of vasculitis is associated with IgA nephropathy?
Henoch-Schonlein IgA small vessel vasculitis
Name the renal complaint:
Frank haematuria + hypertension + 1 week history of URTI
Post infectious glomerulonephritis
What increase in serum creatinine is seen in AKI level 1 in children?
Over to or equal to 1.5x
What happens to calcium and phosphate levels in AKI?
Calcium drops, phosphate rises
Which drugs should be held in AKI?
DAMN drugs:
Diuretics, ACE inhibitors, metformin, NSAIDs
Name the renal complaint:
Haemolytic anaemia + thrombocytopenia + AKI
Haemolytic uraemic syndrome
Name the renal complaint:
History of bloody diarrhoea + AKI
Haemolytic uraemic syndrome
Name the renal complaint:
Oliguria + hypertension + rising creatinine
AKI
What percentage of kidney function needs to be lost before GFR is impaired?
40%
What affect does kidney disease have on sodium and potassium levels?
Sodium decreases (hyponatraemia)
Potassium increases (hyperkalaemia)
In what age group should we not use urine dipstick testing in?
Under 2
How many colony forming units per millilitre of culture is diagnostic in UTI?
10^5
What is the gold standard for diagnosing vescico-ureteric reflux in children?
Micturating cysto-urethrogram
How many days should we administer antibiotics in children with lower tract UTI symptoms?
3 days
How many days should we administer antibiotics for in children with pyelonephritis/upper tract UTI?
7-10 days; oral if systemically well, IV if not
Which GI symptom may predispose children to UTI?
Constipation
What happens to phosphate levels in kidney disease?
Increases
Increased phosphate in kidney disease leads to the increase of what hormone? This can lead to damage to which part of the body?
PTH; damage to bones - metabolic bone disease
A child presenting with a groin swelling is most likely what?
Inguinal hernia
At what age should we urgently refer children with inguinal hernia?
Under 1 year old
Name the urological complaint:
Painless scrotal swelling which transilluminates
Hydrocele
Non retractile foreskin will require what treatment?
Circumcision
How many hours do we have to save testicles in testicular torsion?
6 hours
Name the urological complaint present:
Blue dot sign
Torsion appendix testis
Name the urological complaint:
Urethral meatus on ventral aspect of penis
Hypospadias
Nuchal thickening seen on USS is an indication for what test?
Amniocentesis
Foetal macrosomia can predispose to what foetal complication during labour?
Shoulder dystocia
What is important to carry out for neonates born to diabetics?
Feeding early
Acute chorioamnionitis can predispose to what condition later in life for the child if not treated successfully?
Cerebral palsy
Cocaine use can predispose to what placental disorder?
Placental abruption
Name the neurological complaint:
Hemicranial pain + vomiting + abdominal pain
Childhood migraine
What medication would we use for migraine prophylaxis in children without AND with asthma?
Without - propranolol
With - amitriptyline
Name the neurological complaint:
Band like headache + constant ache
Tension headache
What medication can we use for tension headache prophylaxis?
Amitriptyline
Up rolling of the eyes and blinking indicates what type of epileptic seizure?
Absence
Do GABA and glutamate levels increase or decrease during epileptic seizures?
GABA - decrease
Glutamate - increase
What medication would we use for generalised seizures in boys?
Sodium valproate
What medication would we use for generalised seizures in girls?
Levetiracetam
What medication would we use for focal seizures in children?
Carbamazepine
What diet may be implicated in drug refractory epilepsy?
Ketogenic
At what age is febrile convulsion most common?
3 months to 5 years
Name the neurological complaint:
X linked + proximal muscle weakness + Gowers sign positive
Duchenne Muscular Dystrophy
Gowers sign positive indicates what?
Pelvic girdle weakness
Which blood test parameter would be significantly elevated in Duchenne muscular dystrophy?
Creatinine kinase