paediatrics Flashcards

1
Q

For a child born in the United Kingdom, at what age would their hearing first be formally assessed?

A

newborn - otoacoustic emission

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2
Q

pyloric stenosis presentation

A

3-6 wks

projectile, non-bilious vomiting
hunger between episodes

olive mass

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3
Q

ix pyloric stenosis

A

USS = thickened pylorus

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4
Q

what would gas show in pyloric stenosis

A

hypochoraemic hypokalaemic metabolic alkalosis

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5
Q

tx pyloric stenosis

A

Rhamsteds op - laproscopic pyloromyotomy

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6
Q

what is hirchsprungs

A

lack of nerve fibres in part of the gut (aganglionic myeteric plexus)

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7
Q

presentation of hirchsprungs

A

just born
failure to pass meconium

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8
Q

ix hirchsprungs

A

full thickness rectal biopsy

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9
Q

tx hirchsprungs

A

anorectal pull through procedure = SWENSON

(after rectal washouts)

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10
Q

what is meckel’s diverticulum

A

an outpouching or bulge in the lower part of the small intestine
The bulge is congenital and is a leftover of the umbilical cord.

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11
Q

presentation meckel’s diverticulum

A

1-2 yrs
bright red GI bleeding

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12
Q

ix meckel’s diverticulum

A

technetium scan

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13
Q

tx meckel’s diverticulum

A

wedge excision surgery if sx

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14
Q

mesenteric adenitis presentation

A

central abdo pain + URTI

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15
Q

mesenteric adenitis tx

A

conservative

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16
Q

what is mesenteric adenitis

A

swollen lymph glands in abdo

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17
Q

presentation cystic fibrosis

A

meconium ileus
bilious vomiting
abdo distension

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18
Q

presentation intussusception

A

6-9 months

sausage shaped mass (RUQ?)
red current jelly stool (late sign)
vomiting (bilious if obstruction)
knees up to chest - colicky pain

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19
Q

ix intussusception

A

USS abdo - doughnut/target sign

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20
Q

tx intussusception

A

rectal air enema / insufflation

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21
Q

duodenal atresia presentation

A

congenital
Downs
polyhydramnios

bilious vomiting

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22
Q

ix duodenal atresia

A

abdo XR = double bubble

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23
Q

tx duodenal atresia

A

duodenoduodenostomy surgery

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24
Q

presentation biliary atresia

A

jaundice >14 days
pale stools, dark urine

in neonates

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25
ix biliary atresia
increased conjugated bilirubin
26
tx biliary atresia
kasai procedure
27
presentation oesophageal atresia
tracheo-oesophageal fistula + polyhydramnios choking and cyanotic spells following aspiration
28
presentation disphragmatic hernia
resp distress after birth bowel sounds tinkling in lung fields assoc w pulmonary hypoplasia
29
tx diaphragmatic hernia
NG tube intubate + ventilate surgery
30
presentation intestinal malrotation
high caecum at the midline volvulus in first few days of life leading to bile stained vomiting
31
ix intestinal malrotation
upper GI contrast study + USS
32
tx intestinal malrotation
laparotomy Ladd's procedure
33
presentation necrotising enterocolitis (NEC)
bilious vomiting distended abdo bloody stools x feeds unwell
34
ix necrotising enterocolitis (NEC)
supine abdo x ray = gas in bowel wall (pneumatosis intestinalis) , dilated bowel loops, wall oedema
35
tx necrotising enterocolitis (NEC)
NBM laparotomy cefotaxime whilst waiting
36
presentation of slipped upper femoral epiphysis (SUFE)
8-15 yrs fat boy, growth spurt exaggerated pain (from small trauma) prefers external rotation
37
ix slipped upper femoral epiphysis (SUFE)
XR (front leg view)
38
tx slipped upper femoral epiphysis (SUFE)
surgery
39
inheritance of duchennes muscular dystrophy
x-linked recessive
40
presentation duchennes muscular dystrophy
boys 3-5yrs weakness in pelvic muscles progressive to all muscles GOWERS SIGN - The child assumes the hands-and-knees position and then climbs to a stand by "walking" his hands progressively up his shins, knees, and thighs. wheelchair by teens LE 23-35 yrs
41
tx duchennes muscular dystrophy
oral steroid creatinine supplements
42
septic arthritis presentation
hot, painful joint systemic sx x weight bear decreased ROM fever > 38.5 increased inflam markers
43
septic arthritis tx
aspirate abx
44
presentation transient synovitis
3-10 yrs needs urgent assessment recent URTI joint pain after this otherwise well
45
ix transient synovitis
joint aspirate under US guidance
46
tx transient synovitis
analgesia safety net
47
RFs developmental dysplasia of the hip (DDH)
breech FHx First born oligohydramnios >5kg foot def
48
presentation Developmental dysplasia of the hip (DDH)
barlows and ortolani unstable, dislocates easily hip asymmetry, decreased range of movement, limp
49
ix Developmental dysplasia of the hip (DDH)
USS
50
tx Developmental dysplasia of the hip (DDH)
pavlik harness < 6 months surgery
51
perthes disease presentation
5-8 yrs boys pain - slow onset - hip + referred to knee limp decreased range of movement no trauma hx
52
what is perthes disease
avascular necrosis of the femoral head
53
ix perthes disease
XR = decreased joint space and decreased size of femoral head early disease can be missed -> MRI
54
tx perthes disease
observation if < 6 yrs older - surgery?
55
what do you give for meningitis >3 months old
IV ceftriaxone
56
what do you give for meningitis < 3 months old
IV cefotaxime + amoxicillin (to cover listeria)
57
what do you give for meningitis prophylaxis for close contacts
ciprofloxacin tablet single dose
58
pink rash with swinging fever
JIA
59
what is screened on the newborn blood spot test
sickle cell disease cystic fibrosis congenital hypothyroidism inherited metabolic diseases severe combined immunodeficiency - sometimes
60
inheritance of congenital adrenal hyperplasia
AR
61
what is congenital adrenal hyperplasia
deficiency of 21-hydroxylase leading to underproduction of cortisol + aldosterone and overproduction of adrogens (testosterone)
62
electrolyte imbalances in severe congenital adrenal hyperplasia and what does that lead to
hyponatraemia hyperkalaemia (as there is deficiency of aldosterone which is needed to cause Na to be retained and K to be excreted) hypoglycaemia - poor feeding - vomiting - dehydration - arrythmias - collapse
63
how to females w CAH present at birth
virilised genetalia enlarged clitoris
64
mild CAH presentation in F
Tall for their age Facial hair Absent periods Deep voice Early puberty skin hyperpigmentation (due to increased ACTH trying to increase cortisol but a byproduct is melanocyte stim hormone)
65
mild CAH presentation in M
Tall for their age Deep voice Large penis SMALL testicles Early puberty skin hyperpigmentation
66
mx of CAH
Cortisol replacement, usually with hydrocortisone, similar to treatment for adrenal insufficiency Aldosterone replacement, usually with fludrocortisone Female patients with “virilised” genitals may require corrective surgery
67
presentation of croup
barking cough stridor (as URTI) low fever hoarse voice increased work of breathing
68
what causes croup
PARAINFLUENZA
69
tx croup
oral dexamethasone single dose
70
emergency croup tx
high-flow oxygen nebulised adrenaline
71
what causes bronchiolitis
Respiratory syncytial virus (RSV)
72
presentation of bronchiolitis
winter <6 months old ex-prem < 2yrs wheeze (LRTI) crackles resp dis URTI 1st? - coryzal sx
73
when to admit px w bronchiolitis
< 3 months pre-existing condition - premature, downs, CF, congenital HD < 50-75% normal milk intake dehydration RR > 70 sats < 92% mod-severe resp distress apnoeas under-confident parents
74
what is given as prevention of bronchiolitis and who to
monthly palivizumab injection to high risk babies - ex-prem, HD
75
what is CF + what is its inheritance
Condition affecting mucus glands Caused by a genetic mutation of the CF gene on chromosome 7. Most common variant is the delta-F508 mutation. This gene codes for cellular channels, particularly a type of chloride channel. AR
76
key consequences of CF gene mutation
Thick pancreatic and biliary secretions that cause blockage of the ducts -> lack of digestive enzymes such as pancreatic lipase in the digestive tract Low volume thick airway secretions that reduce airway clearance -> bacterial colonisation and susceptibility to airway infections Congenital bilateral absence of the vas deferens in males. Patients generally have healthy sperm, but the sperm have no way of getting from the testes to the ejaculate -> male infertility
77
first sign of CF
meconium ileus - abdo dis + vomiting
78
symptoms of CF
Chronic cough Thick sputum production Recurrent RTIs Loose, greasy stools (steatorrhoea) due to a lack of fat digesting lipase enzymes Abdominal pain and bloating Parents may report the child tastes particularly salty when they kiss them, due to the concentrated salt in the sweat Poor weight and height gain (failure to thrive) pancreatitis
79
signs of CF
Low weight or height on growth charts Nasal polyps Finger clubbing Crackles and wheezes on auscultation Abdominal distention
80
CF dx
Newborn blood spot testing The sweat test is the gold standard for diagnosis - high Cl conc Genetic testing for CFTR gene can be performed during pregnancy by amniocentesis or chorionic villous sampling, or as a blood test after birth
81
how do px w CF prevent s. aureus infections
take long term prophylactic flucloxacillin
82
hardest coloniser to get rid of in CF
Pseudomonas Aeruginosa
83
murmur in ventricular septal defect (VSD)
pan systolic at left sternal edge systolic thrill on palpation
84
what are VSDs assoc w
downs turners
85
sx of VSD
poor feeding dyspnoea tachypnoea failure to thrive
86
tx of VSD
small - watch transvenous catheter closure via femoral vein / open heart surgery there is an increased risk of infective endocarditis - abx proph in surgeries
87
when do you dx pyelonephritis
A temperature greater than 38°C or Loin pain or tenderness
88
sx of UTI in babies
Fever Lethargy Irritability Vomiting Poor feeding Urinary frequency
89
sx of UTI in older children
Fever Abdominal pain, particularly suprapubic pain Vomiting Dysuria (painful urination) Urinary frequency Incontinence
90
ix UTI
clean catch urine dipstick - nitrites (bacteria break down nitrates into this) - leukocytes both = UTI nitrites = UTI just leukoctyes = no UTI if either are present send to microbio lab
91
< 3 months with fever
IV abx full septic screen consider LP
92
UTI > 3 months
oral abx if otherwise well usually: trimethoprim nitrofuratoin cefalexin amoxicillin
93
when to do USS in UTI
- < 6 months with their first UTI. Do within 6 weeks, during if recurrent / atypical bacteria - recurrent UTIs - within 6 weeks - atypical UTIs - during the illness
94
how to assess damage from recurrent UTIs
DMSA scan 4-6 months after illness
95
what is Vesico-Ureteric Reflux (VUR)
where urine has a tendency to flow from the bladder back into the ureters. This predisposes patients to developing upper urinary tract infections and subsequent renal scarring
96
how is VUR dx
micturating cystourethrogram (MCUG
97
when to do MCUG
used to investigate atypical or recurrent UTIs in children under 6 months It is also used where there is: - a family history of vesico-ureteric reflux - dilatation of the ureter on ultrasound - poor urinary flow
98
nephrotic syndrome triad
Low serum albumin High urine protein content (>3+ protein on urine dipstick) Oedema
99
other features of nephrotic syndrome
Deranged lipid profile, with high levels of cholesterol, triglycerides and low density lipoproteins High blood pressure Hyper-coagulability, with an increased tendency to form blood clots
100
most common cause of nephrotic syndrome
minimal change disease
101
mx of nephrotic syndrome
high dose steroids - pred - for 4 wks then ween low salt diet diuretics albumin infusions abx proph
102
what to use in steroid resistance children w nephrotic syndrome
ACE inhibitors and immunosuppressants such as cyclosporine, tacrolimus or rituximab
103
EEG in absence seizure
3-hertz spike + wave discharges
104
tx of absence seizure
ethosuximide
105
what triggers myoclonic juvenile jerk
lack of sleep
106
what is strabismus
misaligned eyes
107
what is amblyopia
affected eye is passive + decreases in func compared to dominant eye
108
what is hypertropia
upward moving affected eye
109
what is hypotropia
downward moving affected eye
110
what is exotropia
outward position squint
111
what is esotropia
inward position squint
112
what to do if child develops new squint
CT head
113
what is whooping cough caused by
bordetella pertussis
114
tx of whooping cough
admit if < 6 months oral macrolide (within 21 days) - clarihtromycin/azithromycin/erythromycin
115
what is epiglottitis caused by
h. influenza
116
tx epiglottitis
IV cefotaxime
117
XR epiglottitis
thumb sign
118
neonatal hypoglycaemia is when there is a level of
< 2.6 mmol/L
119
what can neonatal hypoglycaemia be caused by
preterm birth (< 37 weeks) maternal diabetes mellitus IUGR hypothermia neonatal sepsis inborn errors of metabolism nesidioblastosis Beckwith-Wiedemann syndrome
120
features of neonatal hypoglycaemia
may be asymptomatic autonomic (hypoglycaemia → changes in neural sympathetic discharge) - 'jitteriness' - irritable - tachypnoea - pallor neuroglycopenic - poor feeding/sucking - weak cry - drowsy - hypotonia - seizures other features may include - apnoea - hypothermia
121
neonatal hypoglycaemia tx
asymptomatic - encourage normal feeding (breast or bottle) - monitor blood glucose symptomatic or very low blood glucose - admit to the neonatal unit - intravenous infusion of 10% dextrose
122
when is hand preferenece abnormal
before 12 months
123
which childhood infections are notifiable
measles scarlett fever rubella
124
measles presentation
KOPLIC spots - grey in cheek rash = head + neck -> rest of body may get conjunctivitis coryzal sz b4
125
complication of measles
otitis media
126
when can you go to school w measles
4 days after rash
127
tx measles
supportive
128
what causes roseola
Human herpes virus 6
129
roseola features
high fever that starts suddenly RASH after fever - rose-pink macules w surrounding pale halo - trunk then limbs simple febrile seizures
130
what causes hand foot + mouth disease
cocksacki A16
131
hand foot + mouth features
blisters on hands + feet ulcerations on tongue fever + cold sx
132
mx hand foot + mouth
supportive
133
what causes impetigo
staph aureus
134
impetigo features
pupuric rash w discrete patches w golden crusts fevers
135
impetigo tx
topical fusidic acid might need oral flucloxacillin if widespread or severe
136
when to go to school w impetigo
48 hrs after abx or until all lesions have healed
137
5 features of Kawasaki disease
high fever 5 + days strawberry tongue cervical lymphadenopathy bilateral conjunctivitis swelling/erythema of extremities
138
ix in kawasaki
FBC = anaemia, leukocytosis and thrombocytosis LFTs = hypoalbuminemia + elevated liver enzymes Inflammatory markers (particularly ESR) are raised Urinalysis = WBCs without infection ECHO to check coronary artery
139
tx kawasaki
high dose aspirin IV immunoglobulins
140
why do you usually avoid aspirin in children
risk of Reye's syndrome
141
what causes chicken pox
VZV <- human herpes virus 3
142
chicken pox features
prodrome of viral sx - fever + lethargy vesicular rash - crusts + forms blisters
143
incubation for chicken pox
3 wks
144
when can you go to school w chicken pox
after all lesions have crusted over
145
rubella features
rash starts on head + spreads to trunk low grade fever postauricular lymphadenopathy
146
when can you go to school w rubella
5 days from rash
147
HSP features
often triggered by an upper airway infection or gastroenteritis purpuric rash on legs + buttocks sore joints nephritis abdo pain
148
features of parovirus B19 / fifths disease / slapped cheek syndrome
red cheeks fever cold sx lace-like rash - once they have this they are no longer infectious
149
tx of parovirus B19 / fifths disease / slapped cheek syndrome
supportive - para / ibu
150
features of scarlett fever
strawberry tongue - peri-oral sparing sandpaper rash fever
151
what causes scarlett fever
group A strep - strep pyrogens
152
tx scarlett fever
10 days phenoxymethylpenicillin
153
when can you go to school w scarlett fever
24 hrs from abx
154
what is turner's syndrome
45 XO FEMALES
155
features of turners
delayed puberty - primary amenorrhoea webbed neck wide nipples short spoon nails otitis media bicuspid aortic valve (ejection systolic murmur) aortic coarctation
156
features of noonan's + its inheritance
AD thought of as male turners webbed neck pectus excavatum pulmonary stenosis (ejection systolic) pulmoNOONanary
157
what is Patau syndrome
trisomy 13
158
features of Patau syndrome
small eyes cleft Palate / lip Polydactyly (does not usually survive)
159
features of pierre-robin
posterior displacement of tongue (you're ROBIN' me of my airway!) cleft palate Micrognathia (undersized lower jaw)
160
what is Edward's syndrome
trisomy 18
161
features of Edward's syndrome
low set ears rock bottomed feet overlapping fingers small jaw
162
features of fragile X
features in males: (females will have one fragile chromosome + one normal so may present more normally) long face large ears large testes learning diff autism more common mitral valve prolapse
163
what is fragile X
trinucleotide repeat disorder
164
features of prader-willi
fat hypotonia hypogonadism
165
features of cri du chat
Characteristic cry due to larynx and neurological problems feeding diff learning diff long distance between eyes
166
what is cri du chat
chromosome 5p deletion syndrome
167
features of William's syndrome
friendly elfin facies learning diff hypercalcaemia supravalvular aortic stenosis
168
what is William's syndrome
inherited neurodevelopmental disorder caused by a microdeletion on chromosome 7
169
most common cause of neonatal sepsis
maternal group B strep infection
170
most common fractures seen in child abuse
- Radial - Humeral - Femoral
171
how does IgA nephropathy present
macroscopic haematuria in young people following an upper respiratory tract infection
172
what is a nephroblastoma (wilms tumour) + how does it present
most common paeds renal cancer presents in first 4 yrs of life a mass associated with haematuria Often metastasise early (usually to lung) Treated by nephrectomy
173
Androgen insensitivity syndrome inheritance
X-linked recessive
174
what is androgen insensitivity syndrome
end organ resistance to testosterone genotypically MALE children (46XY) but with FEMALE phenotype
175
features of androgen insensitivity syndrome
primary amenorrhoea undescended testes causing groin swellings breast dev may occur as a result of conversion of testosterone to oestradiol
176
mx androgen insensitivity syndrome
counselling - raise child as female bilateral orchidectomy (increased risk of testicular cancer due to undescended testes) oestrogen therapy
177
what is kallman's syndrome
genetic condition causing of delayed puberty 2ndary to hypogonadotrophic hypogonadism (prob w pituitary)
178
kallman's syndrome inheritance
X-linked recessive
179
what is hypogonadism
lack of the sex hormones, oestrogen and testosterone either due to hypogonadotrophic hypogonadism or hypergonadotrophic hypogonadism
180
what is hypogonadotrophic hypogonadism
deficiency of LH and FSH, leading to a deficiency of the sex hormones testosterone and oestrogen a result of abnormal func of the hypothalamus or pituitary
181
what is hypergonadotrophic hypogonadism
where the gonads fail to respond to stimulation from the gonadotrophins (LH and FSH) no -ve feedbacl so get increasing amounts of FSH + LH
182
features of kallman's syndrome
boy 'delayed puberty' hypogonadism, cryptorchidism anosmia (LACK OF SMELL) sex hormone levels are low LH, FSH levels are inappropriately low/normal patients are typically of normal or above average height
183
what is klinefelter's syndrome
47, XXY Primary hypogonadism
184
features of klinefelter's syndrome
often taller than average lack of secondary sexual characteristics small, firm testes infertile gynaecomastia - increased incidence of breast cancer elevated gonadotrophin levels
185
examination w PDA
left subclavicular thrill continuous 'machinery' murmur large volume, bounding, collapsing pulse wide pulse pressure heaving apex beat
186
what is PDA
congenital heart defect connection between the pulmonary trunk and descending aorta usually, the ductus arteriosus closes with the first breaths due to increased pulmonary flow which enhances prostaglandins (which keep the duct open) clearance more common in premature babies, born at high altitude or maternal rubella infection in the first trimester
187
mx PDA
indomethacin or ibuprofen - given to the neonate - inhibits prostaglandin synthesis - closes the connection in the majority of cases
188
RFs for neonatal sepsis
Mother who has had a prev baby with GBS infection, who has current GBS colonisation from prenatal screening, current bacteruria, intrapartum temperature ≥38ºC, membrane rupture ≥18 hours, or current infection throughout pregnancy Premature (<37 weeks): approximately 85% of neonatal sepsis cases are in premature neonates Low birth weight (<2.5kg): approximately 80% are low birth weight Evidence of maternal chorioamnionitis
189
features in tetralogy of fallot
Ventricular septal defect (VSD) Overriding aorta Pulmonary valve stenosis Right ventricular hypertrophy
190
RFs tetralogy of fallot
Rubella infection Increased age of the mother (over 40 years) Alcohol consumption in pregnancy Diabetic mother
191
s+s tetrallogy of fallot
Cyanosis (blue discolouration of the skin due to low oxygen saturations) Clubbing Poor feeding Poor weight gain Ejection systolic murmur heard loudest in the pulmonary area (second intercostal space, left sternal border) “Tet spells”
192
when does a baby smile responsively
6-8 wks
193
when does a baby raise head to 45 deg prone
6-8 wks
194
when does a baby follow a moving object/face
6-8 wks
195
what is the limit for a baby to sit up
9 mths
196
what is the limit for a baby to transfer objects between hands
9 mths
197
what is the limit for mature pincer grip
12 mths
198
what is the limit for walking
18 mths
199
vaccine schedule
2m - 6in1, rotavirus, Men B 3m - 6in1, rotavirus, PCV 4m - 6in1, Men B 1yr - MMR, PCV, Men B, 2in1 3-4yrs - MMR, 4in1 12yrs - HPV 13-14yrs - 3in1, Men ACWY 2-8 yrs annual flu vaccine
200
what is in the 6in1 vaccine + when do you get it
diptheria tetnus polio pertussis Hib Hep B 2, 3, 4 months
201
what is in the 2in1 vaccine + when do you get it
Hib, Men C 1yr
202
what is in the 4in1 vaccine + when do you get it
diptheria tetnus polio pertussis 3-4yrs
203
what is haemolytic disease of the newborn
immune condition that develops when a rhesus -ve mother becomes sensitised to the rhesus +ve blood cells of her baby whilst in utero
204
pre-delivery features of haemolytic disease of the newborn
hydrops foetalis - fetal oedema in at least 2 compartments (pericardial effusion, pleural effusion, ascites) yellow coloured amniotic fluid
205
post delivery features of haemolytic disease of the newborn
jaundice + kernicterus foetal anaemia hepato/splenomegaly severe oedema
206
what is Epstein's pearl
congenital cyst found in the mouth found in posterior hard palate no tx, spontan resolve
207
what are Bohn's nodules
smooth white cysts found on the gums
208
what is gastroschisis
a congenital defect in the anterior abdominal wall just lateral to the umbilical cord (no peritoneal covering)
209
what is exomphalos (omphalocoele)
the abdominal contents protrude through the anterior abdominal wall but are covered in an amniotic sac formed by amniotic membrane and peritoneum
210
mx of exomphalos (omphalocoele)
c section is indicated to reduce the risk of sac rupture a staged repair as primary closure may be difficult due to lack of space/high intra-abdominal pressure, need to allow lung adaptation
211
mx gastroschisis
surgical correction ASAP - cover with cling-film(since no peritoneal covering)
212
components of feverPAIN score
fever in last 24 hrs Pus/Purulent tonsils Attended
213
choice of tx based on feverPAIN score
0-1 = no abx 2-3 = 3 day back up prescription 4+ = abx (higher likelihood of being steptococci) if antibiotics are indicated then either phenoxymethylpenicillin or erythromycin (if the patient is penicillin allergic) should be given. Either a 7 or 10 day course should be given
214
indications for tonsillectomy
7 eps 1 yr 5 eps in the prev 2 yrs each 3 eps a yr for 3 yrs
215
diet advice for CF
High calorie and high fat with pancreatic enzyme supplementation for every meal
216
what to give for neonatal abstinence syndrome (NAS) w non-opiates?
phenobarbital
217
threadworm bacteria
Enterobius vermicularis
218
threadworm tx
mebendazole (an anthelmintic ) single dose for all the household alongside hygiene measures