gynae Flashcards
what is a krunkenburg tumour
development of mets to the ovary
what to do when having surgery if on the pill
stop 4 wks before
first line for urge incontinence
bladder retraining for a min of 6 wks (gradually increasing the time between voiding)
first line for stress incontinence
pelvic floor muscle training
8 contractions 3x/day for at least 3 mths
first-line in the management of nausea & vomiting in pregnancy/hyperemesis gravidarum
antihistamines - oral cyclizine or promethazine
ondansetron is second line
RFs of Hyperemesis gravidarum
increased levels of beta-hCG
- multiple pregnancies
- trophoblastic disease
nulliparity
obesity
family or personal history of NVP
Referral criteria for nausea and vomiting in pregnancy
Continued nausea and vomiting and is unable to keep down liquids or oral antiemetics
Continued nausea and vomiting with ketonuria and/or weight loss (greater than 5% of body weight), despite treatment with oral antiemetics
A confirmed or suspected comorbidity (for example she is unable to tolerate oral antibiotics for a urinary tract infection)
dx of Hyperemesis gravidarum
5% pre-pregnancy weight loss
dehydration
electrolyte imbalance
cervical smear: what to do if the sample is Positive hrHPV
samples are examined cytologically
cervical smear: what to do if the sample is Positive hrHPV and abnormal cytology
colposcopy
cervical smear: what to do if the sample is Positive hrHPV and normal cytology
repeat test at 12 months
if the repeat test is now hrHPV -ve → return to normal recall
if the repeat test is still hrHPV +ve and cytology still normal → further repeat test 12 months later:
If hrHPV -ve at 24 months → return to normal recall
if hrHPV +ve at 24 months → colposcopy
(ie test HPV 3x b4 colposcopy)
what to do if cervical smear sample is inadequate
repeat the sample within 3 months
if two consecutive inadequate samples then → colposcopy
medical mx of abortion
mifepristone (an anti-progestogen)
followed by misoprostol (a prostaglandin) 48 hrs later
take a multi-level preg test after 2 wks to check (Quantitative hCG measurement )
causes of primary amenorrhoea
gonadal dysgenesis (e.g. Turner’s syndrome) - the most common causes
testicular feminisation
congenital malformations of the genital tract
functional hypothalamic amenorrhoea (e.g. secondary to anorexia)
congenital adrenal hyperplasia
imperforate hymen
causes of secondary amenorrhoea (after excluding pregnancy)
hypothalamic amenorrhoea (e.g. secondary stress, excessive exercise)
polycystic ovarian syndrome (PCOS)
hyperprolactinaemia
premature ovarian failure
thyrotoxicosis*
Sheehan’s syndrome
Asherman’s syndrome (intrauterine adhesions)
what is gonadal dysgenesis + what might be the examination findings
congenital condition in which the gonads are atypically developed, and may be functionless
e.g. turners syndrome
Due to the abnormal gonads, androgens are not produced in response to FSH and LH from the anterior pituitary gland. -> absent 2ndary sex characteristics
FSH + LH remain high as no -ve feedback
ix for ectopic preg
transvaginal ultrasound
when to do expectant mx for ectopic
size < 35mm
unruptured
asx
no fetal heartbeat
hCG <1,000IU/L
Compatible if another intrauterine pregnancy
what does expectant mx for ectopic involve
closely monitoring the px over 48 hours and if B-hCG levels rise again or symptoms manifest intervention is performed
when to do medical mx for ectopic
Size <35mm
unruptured
no signif pain
no fetal heartbeat
hCG <1,500IU/L
Not suitable if intrauterine pregnancy
what does medical mx for ectopic involve
methotrexate
needs to attend follow up
when to do surgical mx for ectopic
Size >35mm
can be ruptured
pain
visible fetal heartbeat
hCG >5,000IU/L
Compatible with another intrauterine pregnancy
what does surgical mx for ectopic involve
Salpingectomy is first-line for women with no other risk factors for infertility (full fallopian tube out)
Salpingotomy (tube not acc removed, opening made) should be considered for women with risk factors for infertility such as contralateral tube damage
PCOS test results
raised LH:FSH ratio
testosterone may be normal or mildly elevated
SHBG is normal to low
rotterdam criteria for PCOS
two out of three of the following:
Oligo and/or anovulation
Clinical and/or biochemical signs of hyperandrogenism
Polycystic ovaries
risk factors for endometrial cancer
excess oestrogen
- nulliparity
- early menarche
- late menopause
- unopposed oestrogen. The addition of a progestogen to oestrogen reduces this risk (e.g. In HRT). The BNF states that the additional risk is eliminated if a progestogen is given continuously
metabolic syndrome
- obesity
- diabetes mellitus
- polycystic ovarian syndrome
tamoxifen
hereditary non-polyposis colorectal carcinoma
protective factors for endometrial cancer
multiparity
combined oral contraceptive pill
smoking (the reasons for this are unclear)
how long should women take HRT for premature menopause
until the age of 50
presentation of intraductal papilloma
clear or blood-stained nipple discharge
tenderness or pain
palpable lump (maybe)
what is intraductal papilloma
warty lesion that grows within one of the ducts in the breast - benign tumour
what is a fibroadenoma
common benign tumours of stromal/epithelial breast duct tissue
features of fibroadenoma
Painless
Smooth
Round
Well circumscribed (well-defined borders)
Firm
Mobile (moves freely under the skin and above the chest wall)
Usually up to 3cm diameter
more common ages 20-40
what to do in fibroadenomas >3cm
surgical excision
what is Mammary duct ectasia
dilation of the breast ducts, often resulting in blockage
features of Mammary duct ectasia
Most common in menopausal women
Discharge typically thick and green in colour
Most common in smokers
clinical features of breast cancer
Lumps that are hard, irregular, painless or fixed in place
Lumps may be tethered to the skin or the chest wall
Nipple retraction
Skin dimpling or oedema (peau d’orange)
two week wait referral for suspected breast cancer for:
An unexplained breast lump in patients aged 30 or above
Unilateral nipple changes in patients aged 50 or above (discharge, retraction or other changes)
what forms part of a triple assessment
Clinical assessment (history and examination)
Imaging (ultrasound or mammography)
Histology (fine needle aspiration or core biopsy)
what pill to use in PCOS + why
COCP - co-cyprindrol
- reduceS hirsutism, acne and regulates periods
what to do in PCOS if wanting preg
weight loss
clomifene - induces ovulation
- Try metformin with it
Laparoscopic ovarian drilling
IVF
most common ovarian cyst
follicular
what is a follicular cyst
type of functional cyst
non-rupture of the dominant follicle
usually regresses after several menstrual cycles
what is a corpus luteum cyst
type of functional cyst
when it does not break down in a cycle w no preg and fills with blood/fluid
may cause pelvic discomfort, pain or delayed menstruation
what is a dermoid cyst
most common benign ovarian tumour
mature cystic teratomas (come from germ cells + contain various tissue types)
assoc w ovarian torsion
what do you see on imaging with a dermoid cyst
rokitansky protuberance
what is a serous cystadenoma
most common benign epithelial tumour
what is the triad in Meig’s syndrome
Ovarian fibroma (a type of benign ovarian tumour)
Pleural effusion
Ascites
Typically occurs in older women. Removal of the tumour results in complete resolution of the effusion and ascites.
when do you need post-partum contraception
21 days after birth
when can you insert IUD after childbirth
within 48 hrs
or
after 4 weeks
candida pres
cottage cheese discharge
vulvitis
itch
tx candida
oral fluconazole single dose
CI in preg
- use detrimazole pessary
trichomonas vaginalis pres
offensive yellow/green frothy discharge
vulvovaginitis
strawberry cervix
trichomonas vaginalis tx
oral metronidazole
bacterial vaginosis pres
offensive thin white/grey fishy discharge
bacterial vaginosis tx
oral metronidazole
gonorrhoea tx
IM ceftriaxone
what increases your risk of breast cancer
anything that increases oestrogen exposure
- early onset periods
- late menopause
- combined HRT
- COCP
- smoking
- obesity
- more dense breast tissue
- FHx
risk factors for cervical cancer
COCP
multiparity
HPV 16, 18, 33
smoking
early sex, increased no of sexual partners
FHx
non attendance to screening
risk factors for ovarian cancer
increased amount of ovulations
age
early onset periods
late menopause
no pregnancies
SO COCP, breastfeeding and pregnancy are protective
BRCA 1 + 2 genes
smoking
obesity
clomifene use
presentation of PID
pelvic pain
abnormal bleeding
dyspareunia
dysuria
fever
cervical excitation
purulent discharge