Paediatic Microbiology

Question 1

UTI treatment in a neonates

2 months old
●Miserable
●Temperature
●Vomiting
●Urine microscopy + for E.Coli
●Admit

Answer 1

E.Coli, IV cefuroxime for 7 days, oral switch to trimethoprim

Question 2

What kind of antibiotic is cefuroxime

Answer 2

Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis.

Question 3

What would grow Urinary tract infection
●2 year-old
●Complex medical history
●Pyrexia
●Increase fits
●Admitted
●Urine for MC&S
●IV antibiotics

Answer 3

E. Coli

Question 4

If the child was on IV cefuroxime with an UTI and still unwell

Answer 4

Change to meropenem

Question 5

What is Meropenem

Answer 5

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.

Question 6

What is a gram positive cocci in clumps?

Answer 6

Staphylococcus aureus

Question 7

What is the treatment of osteomyelitis/septic arthritis in older than 3 months

Answer 7

IV cefuroxime
Liaise with microbiologist
Treat for 6 weeks