Growth And Puberty Flashcards

1
Q

Why do you measure children?

A

They provide a sensitive indication of health in childhood. Great rates and narrowly defined and healthy children with adequate nutrition and emotional supportive environment. Changes and great for it can provide an early insensitive point to healthcare problems in children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are important determinants of growth

A

Parental phenotype and genotype, quality and duration of pregnancy, nutrition, specific set stem and organ integrity, psychosocial environment, growth promoting hormones and factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is another word for Growth?

A

ChrondroGenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are regulators of growth

A

Endocrine signals, nutrition, inflammatory cytokines, Extracellular fluid, oxygen deficiency, acidosis, toxins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What factors are measured in growth?

A

Parental height, weight gain, social inequalities and ethnic background

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the different stages of the assessment of growth?

A
  1. initial measurement - Routine screening, on the basis of concern
  2. recording
  3. interpretation
  4. action - If no concern = Continue routine chat
    - if possible concern = specific plan and follow-up to aid evaluation
    - if great concern = referral for fuller assessment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is achondroplasia

A

genetic disorder whose primary feature is dwarfism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the condition associated with short limbs

A

Hypochondroplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is associated with short back and long legs

A

Delayed puberty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does head circumference interpretation depend on

A

Centile position, adherence to or deviation from a centre position with serial measurements, relation to body size degree of correlation with length forward – height and weight centile positions, features of sutures and fontanelles and evidence of abnormal intercranial pressure, familial factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are reasons of unreliable measurements of head circumference

A

Inaccuracy- faulty technique, faulty equipment

Uncooperative child, different observers, different times of the day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What equation predicts a boy’s height

A

Fathers height plus (mothers height +12.5 cm) divided by two

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What equation predicts a girls height

A

Mothers height plus (fathers height -12.5 cm) divided by two

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

When do you have the fastest growth rate

A

In utero and infancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

When does Growth end

A

Fusion of epiphyses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What stage do you use to measure puberty?

A

Tanner staging

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is Tanner stage 1 in boys?

A

Pre-puberty no pubic hair
Testicular length less than 2.5 cm
Test stick your volume less than 3 millilitres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is Tanners stage two in boys

A

Sparse growth of slightly curly pubic hair, mainly at the base of peanuts
Testes larger than 3 mL and larger than 2.5 cm and longest diameter
Scrotum thinning and reddening

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is Tanners stage three in boys

A

Thicker and curlier hair spread to Mons PUbis

Growth of penis in width and length further growth of testes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is Tanner is stage four in boys

A

Adult type hair Not yet spread to medial surface of thighs
Penis further enlarged
Testes larger
Darker scrotal skin colour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is stage five of Tanners in boys

A

Adult type hair spread to meet your surface of phis thighs

Genitalia adult size and shape

22
Q

What is Klinefelter syndrome?

A

genetic condition that results when a boy is born with an extra copy of the X chromosome. Klinefelter syndrome is a genetic condition affecting males, and it often isn’t diagnosed until adulthood.
Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue. The effects of Klinefelter syndrome vary, and not everyone has the same signs and symptoms.

23
Q

What chromosomes does someone with Klinefelter syndrome have

24
Q

What is the presentation of Klinefelter syndrome

A
Primary hypogonadism
Azoospermia and gynaecomastia
Reduced secondary sexual hair
Osteoporosis 
Tall stature 
Reduced IQ in 40%
20% increase in breast cancer
25
What is the HPG axis?
From the hypothalamus GnRH released, to the anterior pituitary gland releasing LH and FSH, To the gonads releasing gonadal sex hormones
26
Where is the problem in primary hypogonadism?
In the gonads
27
Where is the problem in secondary hypogonadism?
Pituitary
28
Where is the problem in tertiary hypogonadism?
Hypothalamus
29
What are causes of hypogonadotrophic hypogonadism
CNS - Tumours - craniopharyngiomas, germinomas - Langerhan’s histiocytosis - post infectious lesions of the CNS - radiation - head trauma Isolated gonadotropin deficiency - kallmann’s syndrome - LHRH receptor mutation - congenital adrenal hypoplasia - LH deficiency - FSH deficiency Miscellaneous - prader willi syndrome - sickle cell disease - CF - AIDS - malnutrition - bulimia - exercise amenorrhea - hypothyroidism - DM - cushing’s - hyperprolactinemia
30
Tanner stage 1 in girls
Prepubertal - no pubic hair | Elevation of papilla only
31
Tanner stage 2 in girls
Sparse growth of long straight or curly minimally pigmented hair mainly on labia Breast bud noted palpable Enlargement of areola
32
Tanner stage 3 in girls
Darker courser hair spreading over mons pubis | Further enlargement of breast and areola with no separation of contours
33
Tanner stage 4 in girls
Thick adult type hair not yet spread to medial surface of thighs Projection of areola and papilla to form secondary mound above level of breast
34
Tanner stage 5 in girls
Hair adult type and distributed in classic inverse triangle | Adult contour breast with projection of papilla only
35
What is turners syndrome?
Turner syndrome, a condition that affects only females, results when one of the X chromosomes (sex chromosomes) is missing or partially missing
36
What is the presentation of turners at birth?
Oedema of dorsa of hands, feet and loose skinfolds at the nape of the neck
37
What is the presentation of turners syndrome
``` Webbing of neck Low posterior hairline Small mandible Prominent ears Epicanthal folds High arched palate Broad chest Cubitus valgus Hyperconvex fingernails Cardiovascular malformation Renal malformation Recurrent otitis media Short stature ```
38
What is the first sign of puberty in girls
Breast budding
39
What is the first sign of puberty in boys
Testicular enlargement
40
What age indicates delayed puberty in girls
Over 13
41
What age indicates delayed puberty in boys?
Over 14
42
What age indicates early puberty in girls?
Under the age of 8
43
What age indicates early puberty in boys
Less than 9
44
What are factors that affect birth weight?
``` Maternal size and weight Parity Gestational diabetes Smoking Paternal size ```
45
What are common causes of short stature?
``` Constitutional slow maturation, delayed puberty Idiopathic Environmental Nutrition Physical disease Skeletal disease Turners syndrome Endocrine ```
46
Chronic diseases that can cause short stature
``` Gastrointestinal- coeliacs, IBD CVS - CHD Renal disease Haematological - chronic severe anaemia Pulmonary - CF, bronchopulmonary dysplasia Chronic inflammation and infection ```
47
What are causes of overgrowth with impaired final height
Precocious puberty Congenital adrenal hyperplasia Mcalbright syndrome Hyperthyroidism
48
What are causes of overgrowth with increased final height
Androgen/oestrogen deficiency/ oestrogen resistance GH excess Klinefelter syndrome XXY Marfans
49
Psycho social short stature
Over 3 years old Emotional rejection key factor Physical sexual abuse can be associated 50% shoe reversible GH deficiency, poor response to GH treatment
50
Obesity drives growth
.
51
Nutritional obesity
Tall and fat
52
Endocrine obesity
Short and fat