PADIS

Question 1

The MENDS Trial by Pandaharipande, 2007 in 103, ICU-patient: Dexmedetomidine Vs Lorazepam

Answer 1

in Mechanically ventilated, patient on Dexmedetomidine had improved coma free days, and time within goal level of sedation but required more fentanyl and had more incidence of bradycardia.

Question 2

The SEDCOM trial by Riker et al, 2009 in 375 ICU, patient: Dexmedetomidine Vs Midazolam

Answer 2

in Mechanically ventilated, patient on Dexmedetomidine was equivalent to Midazolam in achieving sedation goals. But Dexmedetomidine had reduced ICU delirium and duration of mechanical ventilation

Question 3

Precautions & Main side effects of Propofol

Answer 3

bradycardia, hypotension, PRIS (propofol induced syndrome) e.g. green urine ,elevated triglyceride levels and Precaution in liver and renal failure

Question 4

Precautions & Main side effects of Dexmedetomidine

Answer 4

bradycardia, hypotension/hypertension, precautions in liver failure