p53 Flashcards
What is the primary function of p53 as a transcription regulator?
Why is p53 considered the “guardian of the genome”?
In which region of p53 do 90% of mutations occur?
Name two other proteins in the p53 family.
What is the main function of p63 in development?
How does p73 contribute to cellular processes?
What is the normal function of p53 in fertility?
Describe Peto’s paradox in relation to cancer rates and body size.
How many copies of p53 does the African savannah elephant genome contain?
What is the Li-Fraumeni syndrome?
How do elephant cells respond to ionizing radiation compared to human cells?
At what stage does p53 inactivation typically occur in colon cancer?
Name two environmental factors that can directly inactivate or cause mutations in p53.
How does the SV40 large T antigen interfere with p53 function?
Describe how adenovirus proteins interact with p53.
What is the role of HPV E6 protein in relation to p53?
How does p53 influence cancer therapy?
Why are tumours with mutant or absent p53 often resistant to therapy?
What is the importance of having two functional p53 alleles in humans?
How does p53 respond to different cellular stresses?
What is the significance of p53 in DNA damage checkpoints?
Describe the relationship between p53 and cancer development in mice with targeted disruption of the p53 gene.
How does p53 function differ between normal cells and cancer cells?
What is the role of p53 in inducing cell cycle arrest or apoptosis?
How do oncogenic viruses target both Rb and p53?
What is the significance of p53 mutations in relation to other genetic lesions in tumours?
How does the Human Papilloma Virus (HPV) E6 protein affect p53 function?
Describe the evolutionary significance of p53 in different species.
What is the relationship between p53 and ribosomal stress?
How does p53 contribute to the body’s response to DNA damage from radiation or chemotherapy?
