P3. Mononuclear Phagocyte System

Question 1

the 8 cell type mononuclear phagocyte

Answer 1

1. monocyte
2. macrophage
3. kupffer cell
4. microglial cell
5. langerhans cell
6. dendritic cell
7. osteoclast
8. multinuclear giant cell

Question 2

Monocyte:

1. major location?
2. main function: precursor of ____.

Answer 2

1. blood
2. macrophages

Question 3

Macrophage can be seen in the following locations:

Answer 3

1. connective tissue
2. lymphoid organs
3. lungs
4. bone marrow
5. pleural & peritoneal cavities

Question 4

cell that produces:
- cytokines
- chemotactic factors
- molecules that participate in: inflammation (defense), Ag processing & presentation.

Answer 4

Macrophage

Question 5

Kupffer cell

1. major location?
2. main function: same as ____.

Answer 5

1. liver (perisinusoidal)
2. macrophages

Question 6

Microglial cells

1. major location?
2. main function: same as ____.

Answer 6

1. central nervous system (CNS)
2. macrophages

Question 7

Langerhans cells

1. major location?
2. main function: ____ processing & presentation.

Answer 7

1. epidermis of skin
2. antigen

Question 8

Dendritic cell

1. major location?
2. main function: ____ processing & presentation.

Answer 8

1. lymph nodes & spleen
2. antigen

Question 9

from fusion of several macrophages

Answer 9

osteoclast

Question 10

Osteoclast

1. major location?
2. main function: localized digestion of ____.

Answer 10

1. bone
2. bone matrix

Question 11

Multinuclear giant cell

1. major location: in ____ under various pathological conditions
2. main function: segregation & digestion of ____

Answer 11

1. connective tissue
2. foreign bodies