P. T Cell Non-Hodgkins Lymphoma (L14) Flashcards
What are the T cell lymphomas/leukemias?
Anaplastic large cell lymphoma (ALCL)
Mycoses Fungiodese/Sezary Syndrome
T cell lymphoma or leukemias generally involve what type of tissue?
Involve extranodal sites like skin, midline facial area & liver
How well does cytology predict prognosis in T cell lymphomas/leukemias?
not very well
What is the most common T cell lymphoma?
Mycosis fungoides
How does the prognosis of nodal T & B cell lymphoma compare
T is much worse. Usually high grade
ALK staining is characteristic of what neoplastic disorder?
Anaplastic Large Cell Lymphoma (ALCL)
What cytogenic abnormality is associated with ALCL? How does prognosis change for a patient + for ALK?
t(2:5) –> ALK
Better prognosis than a patient that is -
What tissues can be effected by ACLC? Which has a better prognosis?
Lymph nodes = worse prognosis
Skin = better prognosis
What grade is ACLC and how often is it cured?
High grade but curable about 75% of the time
How does a lymph node biopsy appear in ACLC?
Very few germinal centers
Tightly packed with highly mitotic cells
How does the likelihood of ACLC change with age?
There is a bimodal age increase
What CD is expressed in ACLC?
30, just like Reed Sternberg
What type of lymphoma is associated with CLL?
Small Lymphocytic Lymphoma (SLL)
What are smudge cell on a peripheral smear diagnostic of?
CLL
What is the pathophysiology of CLL?
Proliferation of small lymphocytes in bone marrow, lmph nodes, spleen and blood
What is the appearance of tumor cells in CLL? Are there neoplastic T or B cells
normal
95% T & 5% B
What causes the complications seen in CLL?
Pancytopenia
CLL can progress into what 2 more aggressive disorders? Where do these disorders mainly act?
PLL = blood
Richter’s Syndrome = Lymph nodes
How does the presence of memory B cells change the prognosis of CLL?
improves
How does the presence of undifferentiated naive B cells change the prognosis of CLL?
worse
What tissue is characteristically effected by Hairy Cell Lymphoma?
B cell proliferative disorder in bone marrow & spleen
What is suspected if see cells with hair like cytoplasmic projections?
Hairy Cell Leukemia
How is the prognosis for Hairy Cell Leukemia?
Very good
What is the clinical manifestation of Hairy Cell Leukemia?
Pancytopenia
Splenomegaly
Dry bone marrow apirate
What is the most common type of Cutaneous T Cell Lymphoma
Mycoses Fungoides
Skin lesions in mycoises fungoides have what appearance?
mushroom like
Pathy rashes that are itchy
What is suggested by a microabscess? What does it look like?
Mycosis Fungoides
Patch of neoplastic cells in a clear space surrounded by darker epidermal cells
Mycosis Fungoides can progress to what?
Sezary Syndrome = cells get into blood (leukemia)
What grade is Mycosis Fungoides?
Low grade
What is suspected when there are ciribriform nuclei?
Sezary Syndrome
What 2 neoplastic disorders have a bimodal age distribution?
Hodgkins
Anaplastic Large Cell Lymphoma
(ALL sort of but really just in young)
What 2 neoplastic disorders express CD 30?
Reed Sternberg of Hodgkins
Anaplastic Large Cell Lymphoma
