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Unit 2 SPATH UFCOM > L. Hodgkins Lymphoma (L12) > Flashcards

L. Hodgkins Lymphoma (L12) Flashcards

1
Q

The presence of what cell type is necessary for the diagnosis of Hodgkins Lymphoma?

A

Reed Sternberg

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2
Q

What is the appearance of Reed Sternberg Cells?

A
  • Large binucleated cells with abundant cytoplasm & multiple nucleoli
  • “Owl eyes”
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3
Q

A majority of the mass in hogkins lymphoma is made up of what?

A

Inflammatory cells that where recruited to the lymph node by cytokines released by the

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4
Q

A majority of the mass in Non-Hodgkin’s Lymphoma made up of what?

A

Neoplastic cells

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5
Q

What surface markers do Reed Sternberg Cells have?

A

CD30 & CD15

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6
Q

What is the origin of Reed Sternberg Cells?

A

• Monoclonal germinal center B cells

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7
Q

How does the likelihood of getting Hodgkins lymphoma change with age?

A
  • Bimodal

* Higher risk in teenagers/young adults and then in the over 50 population

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8
Q

How is the incidence of Hodgkins lymphoma changing? How about NHL?

A

Incidence is increasing slightly for HL

Large increase in NHL

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9
Q

Does NHL and/or HL have prominent background cells?

A

• Hodgkins does and NHL doesn’t

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10
Q

Do males or females generally get Hodgkins lymphoma more often? Exception?

A
  • Males

* Except in sclerosing type (young females most common)

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11
Q

What other conditions increase the risk for Hodgkins Lymphoma?

A
  • EBV

* HIV & other immunodeficiencies

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12
Q

What are B symptoms? Are they present in HL or NHL? What causes them?

A
  • Fever
  • Night Sweats
  • Fatigue
  • Weight Loss
  • HL, not NHL
  • Caused by cytokines being released by Reed Sternberg
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13
Q

How does Hodgkins Lymphoma Present?

A
  • Painless lymphadenopathy
  • B symptoms
  • Itchy skin
  • Continuous spread through body/lymph nodes
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14
Q

Does continuous spread through lymph nodes/tissue suggest HL or NHL?

A

Hodgkins Lymphoma

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15
Q

What is the most common subtype of Hodgkin’s Lymphoma?

A

Nodular Sclerosis

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16
Q

Who is most likely to get Nodular Sclerosis?

A

Young Females

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17
Q

Lacunar Cells and fibrous bands through bone marrow are signs of what condition?

A

• Nodular Sclerosis (Hodgkins Lymphoma)

18
Q

What is the general prognosis for Hodgkin’s Lymphoma Patients?

A

• Pretty good, about 80% 5 yr survival rate

19
Q

Does NHL or HL have the better prognosis?

A

HL

20
Q

Is Hodgkin’s Treatment based more on staging or morphological features?

A

Staging

21
Q

Is extranodal disease characteristic of NHL or HL?

A

NHL

22
Q

How much of the mass in Hodgkin’s Lymphoma is made up of neoplastic cells?

A
  • Small percentage

* Few Reed Strenberg Cells which secrete cytokines to bring in inflammatory cells

23
Q

Which Hodgkin’s subtype has the best prognosis? Worst Prognosis?

A
  • Lymphocytic Rich

* Lymphocytic Depleted

24
Q

What are the neoplastic cells in Hodgkins Lymphoma?

A

Reed Sternberg Cells

25
Q

Which is more common, HL or NHL?

A

NHL

26
Q

Are systemic symptoms seen in HL or NHL?

A

HL

27
Q

Is “multicentric” disease suggestive of NHL or HL?

A

NHL

28
Q

Are Reed Sternberg cells monoclonal or polyclonal?

A

Monoclonal

29
Q

Where in the body does Nodular sclerosis most often present?

A

Mediastinum

30
Q

How is flow cytometry used to diagnose HL?

A

• It isn’t useful for this purpose

31
Q

What are the two main subtypes of HL? Which is more common?

A

Classical HL
Nodular Lymphocytic Predominant HL
CHL account for about 95% of HL

32
Q

What are the 4 types of Classical HL?

A 
Nodular sclerosis (NS) 
Lymphocyte depletion (LD)
Lymphocyte rich (LR)
Mixed cellularity (MC)
33
Q

Is HL curable?

A

Yes (about 75% of the time)

34
Q

Is NHL curable?

A

Sort of (<50% of the time)

35
Q

What is the cell type that is neoplastic in NHL? What stage of differentiation is present?

A 
B cells (85%) & T cells (15%)
Various stages of differentiation
36
Q

HL makes up what percentage of lymphomas?

A

40%

37
Q

Are NL & NHL related to neoplastic lymphocytes and/or granulocytes?

A

Lymphocytes only

38
Q

The ingestion of what can worsen the itching seen in some patients with HL?

A

Alcohol

39
Q

What causes Reed Sternberg Cells?

A

During fixation reed staernberg cells pull away from surrounding leaving an empty space around them that is an artifact

40
Q

Cytokines released from Reed Sternberg Cells do what 2 things?

A

Recruit inflammatory background cells

Cause B symptoms

Unit 2 SPATH UFCOM (17 decks)

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