Oxygen and Cancer

Question 1

What are 3 potential therapeutic targets for HIF?

Answer 1

Anemia (chronic kidney disease)
Ischemia
Inflammation

Question 2

How is anemia treated?

Answer 2

Proyl hydroxylase inhibitors

Question 3

Why are PHIs used instead of erythropoietin?

Answer 3

1% of population hate needles but PHIs can be taken by tablet
Or others who don’t have access to clinical sites
PHI work better than EPO in chronic kidney disease

Question 4

How is ischemia treated?

Answer 4

Infuse with PHI to promote adaptive angiogenic or glycolytic response to hypoxia

Question 5

What is a PHI used in inflammatory disease?

Answer 5

DMOG

Question 6

What response do tumour tissue utilise

Answer 6

Angiogenic response mediated by HIF

Question 7

How is this cancer angiogenic response prevented?

Answer 7

HIF inhibitors
VEGF blockers

Question 8

What is the Warburg effect?

Answer 8

switches on glycolysis even if there is oxygen oxygen independent growth