Overview of Neuroanatomy Flashcards
What does the neural plate form in the 4th week?
Neural tube
What differentiates into the neural plate?
Central part of the ectoderm.
The neural tube differentiates along dorsal/ventral axis by what two groth signaling factors?
Shh and BMP
Which neurulation involves columnarization of an existing epithelium, and then rolling or folding the epithelium?
Primary
Which neurulation is characterized by condensation of mesenchyme to form a rod, which then undergoes an epithelial transition to form the neural tube?
Secondary
The neural tube closes as a result of five seperate waves of closure rather than simple two-way zipper-like action during days 19-21. What is the order of closure locations?
- Brain stem and upper spinal cord
- Head (top)
- Face
- Neck
- Caudal region where the sacral part of the spinal cord fuses with the rest of the spinal cord
What needs to close for complete CNS formation?
Rostral and caudal neuropores
What condition is characterized by lack of skull and cerebrum formation with only a brain stem intact due to failure of wave 2 closure?
Anencephaly
What condition is characterized by incomplete formation of both the spinal cord and the overlying vertebrae which remain unfused and open due to incomplete closure of caudal neuropore at the junction of waves 1 and 5?
Spina bifida
What does the myelencephalon become?
Medulla
What does the metencephalon become?
Pons
What does the mesencephalon become?
Midbrain
What does the diencephalon become?
Thalamus, hypothalamus, epithalamus
What does the telencephalon become?
Cerebral hemispheres
What anatomical feature ensures that optical axes are at right angles to vertebral column?
Cephalic flexure
What anatomical feature is located where areas of 4th ventricle and pons enlarge and is where the cerebellum is derived from edge of pons?
Pontine flexure
The dorsal root carries what type of nerve fibers?
Sensory
The ventral root carries what type of nerve fibers?
Motor
Grey matter of the spinal cord is broken down into functionally specific areas. What is name of the system that describers these areas?
Rexed’s lamina
Where are afferent axons that convey tactile, proprioceptive, pain and temperature sensations to neurons in lamina 2-4 and split and send branches rostrally and caudally?
Dorsal horn
Where are efferent motor neurons that project to muscle groups?
Ventral horn
What are spinal tracts within white matter formed by?
Axons of ascending and descending neurons
Which funiculus carries tactile, proprioceptive and visceral axons to brain stem?
Dorsal funiculus
What are the three tracts that make up the lateral funiculus?
Lateral corticospinal
Spinocerebellar
Anterolateral system
Which tract is the major descending motor tract from cortex?
Lateral corticospinal tract
Which tract carries tactile and proprioceptive information to cerebellum?
Spinocerebellar tracts
What tract conveys pain and temperature to thalamus (where secondary neurons cross midline and ascend in white matter)?
Anterolateral tract