Overview of IV muscle relaxant agents Flashcards
quiz 2
describe muscle relaxants
interfere with physiological sequence of neuromuscular transmission
NOT anesthetics
used to optimize the surgical condition
acetylcholine is rapdibly metabolized to __ & ___
acetate and choline
ACH metabolized by ____ or ____
acetylcholinesterase/true cholinesterase OR specific cholinesterase
succinylcholine is metaboized by ___
plasma cholinesterase/ pseudocholinterase
two types of neuromuscular blocking agents
depolarizers and nondepolarizers
depolarizers
resemble Ach
bind to Ach receptors generating an action potential
concentration at the NMJ falls slowly, producing depolarization
continuous depolariztion causes muscle relaxation
what kind of muscle relxant is succinylcholine
depolarizing blocking agent
other names for succinylcholine
anectine, succ, suxamethonium, diacetylcholine, quelicin
doses for succinylcholine
dose: 1-1.5 mg/kg/IV
laryngospams- 0.2-0.5 mg/kg/IV
Kids: 2-3 mg/kg/IV
kids or adults: 4-6mg/kg/IM
succinylcholine is metabolized into ____
succinylmonocholine
onset and duration of succinylcholine
onset-30-60 sec
duration 5-10 min
succinylcholine can be prolonged by high doses or abnormal metabolism, such as ____
decreased enzyme levels
pregnancy
liver/renal failure
what meds can prolong succinylcholine duration
echothiophate- glaucoma
cyclophosphamide/mechlorethamine
neostigmine/phyridostigmine
cardiovascular side effects of succinylcholine
stimulates all Ach receptors in SNS/PSNS
bradycardia, especially in kids or with 2nd dose in adults
side effects of succinylcholine
bradycardia
hyperkalemia
fasciculations
muscle pains
malignant hyperthermia
