Overview of Immune System Flashcards
1
Q
What are some barriers against infection?
A
- lysozyme in tears
- skin
- mucus and cilia
- stomach acid
2
Q
How does phagocytosis occur?
A
- chemotaxis
- attachment of microbe to macrophage plasma membrane
- englufment to form phagosome
- phagolysome formed
- kill micorbe
- residual body releases indigestible material
3
Q
Role of phagocytosis?
A
- protection from pathogens
- antigen presenting cells
- disposal of apoptotic cells
- activate adaptive immune response
- link innate and adaptive immunity
4
Q
What do toll-like receptors do?
A
- Phagocytes recognise pathogen associated molecular patterns
- stimulate production of inflammatory cytokines
- phagocytes complement receptors allowing them to attach to complement coated (opsonins) microorganism
5
Q
What is an antibody?
A
- Y-shaped
- tetrameric protein
- two identical heavy chains
- two identical light chains (kappa or lambda)
6
Q
When are immunoglobulins made?
A
- IgM first
- IgG made later to infection
7
Q
How do T cells recognise antigens?
A
CD4+ T cells have receptors which recognise MHC 2 on antigen presenting cells.
8
Q
What are the two groups of MHC?
A
- CD8+ T cells can only detect MHC 1 (all nucleated cells).
- CD4+ T cells can only detect MHC 2 on APC (dendritic/macrophages).
