Overview of Cell-Mediated Immunity Flashcards
Describe the types of microbes combated by cell-mediated immunity.
Phagocytes- Intracellular bacteria, Fungi, Protozoa, phagocytosed microbes that survive in phagolysosome
Nonphagocytic cell - viruses, Protozoa
Describe the functions and properties of major cytokines produced by CD4+ helper T cells, including IL-2, IL-4, IL-5, IL-17, IFN-gamma, TGF-B
IL-2 - survival, proliferation, differentiation of effector and regulatory T cells (produced by CD4, CD8 T Cells)
IL-4 - B cell switch to IgE - produced by CD4 Tcells, mast cells
IL-5 - Activation of eosinophils - produced by CD4
IFN-gamma - Activation of Macrophages
IL-17 - Stimulation of acute inflammation
TGF-B - Inhibition of T cell activation
Compare and Contrast the characteristic and functions of CD4+ Th1, TH2, and TH17 cells in cell mediated immunity
Th1 - produces IFN-gamma
Th2 - produces IL-4, IL-5
TH17 - produces IL-17, IL-22 - promotes epithelial barrier functions
