Overview of Bleeding Disorders Flashcards
Describe the sxs of a primary hemostatic defect (clinical bleeding patterns)
- prolonged initial bleed
- bruising
- nose bleeds
- dental bleeding
- menorrhagia
Describe the sxs of a secondary hemostatic defect (clinical bleeding patterns)
- delayed bleeding
- re-bleeding
- joint bleeds
- soft tissue/muscle bleeds
- extensive bruising
Describe the etiology of thrombocytopenia
Describe the etiology of immune thrombocytopenic purpura (ITP)
Describe the presentation of immune thrombocytopenic purpura (ITP)
Describe the labs/diagnostic testing for immune thrombocytopenic purpura (ITP)
Describe the treatment for immune thrombocytopenic purpura (ITP)
Describe two platelet surface glycoprotein defects
Describe two platelet granule/secretion defects
What can cause acquired platelet function defects
- drugs (ASA)
- bone marrow disorders (MDS)
- renal failure/uremia
Describe the etiology of von Willebrand Disease
PRIMARY HEMOSTATIC DISORDER
Describe the presentation of von willebrand disease
Describe the labs/diagnostic testing for von willebrand disease
Describe the treatment for Von Willebrand Disease
Describe the etiology of hemophilia
Describe the presentation of mild, moderate, to severe hemophilia
Describe the lab testing for hemophilia
Describe some causes of acquired secondary hemostatic disorders
- coag factor inhibitors
- vitamin K deficiency (gut flora, diet)
- liver disease
Which coag factors are vitamin K dependent
- II
- VII
- IX
- X
(also protein C and S)
How do liver related primary/secondary hemostatic defects present
- thrombocytopenia
- decreased synthesis of clotting factors
- dysfunctional fibrinogen
- excess fibrinolysis
Describe the agents working in hemostatic balance
procoagulants
- endothelium
- platelets
- clotting factors
- fibrinolytic inhibitors
VS
anti-coagulants
- protein C
- protein S
- antithrombin
- plasmin
