Overview Flashcards
Where are the kidneys located anatomically?
Retroperitoneal
Which muscles surround the kidneys?
Quadratus lumborum
Psoas major
In relation to the spine where do the kidneys lie
Right - L1 -L3
Left T12 -L2
Are the floating ribs anterior or posterior to the kidney?
Posterior
Where does renal lymph drain to?
Lumbar nodes
Where does ureter lymph drain?
Lumbar and iliac nodes
At what level do the ureters turn medially?
Ischial spine
What zone of the prostate is felt on DRE?
Peripheral
Name the three types of male urethra
- membranous
- prostatic
- spongy
Describe the male ejaculation pathway
Seminiferous tubules Epididymis Vas deferens Prostatic urethra Spongy urethra
What makes up the spermatic cord?
Purple dicks contribute to a good sex life Pampiniform plexus Ducutus deferens Cremasteric artery Testicular artery Artery of ductus deferens Genitofemoral nerve Sympathetics Lymphatics
What is the blood supply to the penis?
Internal pudendal artery
What is the lymph drainage of the penis?
Superficial inguinal
What is the lymphatic drainage of the testes?
Lumbar nodes around abdominal aorta
What cells line the prostate?
Columnar secretory epithelium
State the five stages of CKD
Stage 1 >90 Stage 2 60-89 Stage 3 30-59 Stage 4 15-29 Stage 5 <15 >3 months
What is the commonest cause of CKD?
Diabetes
What is uraemic frost?
Urea deposits from sweat crystallise on skin
Describe CKD management
ACEi/ARB
Renal replacement therapy
What are the complications of CKD?
Anaemia
Renal bone disease
How is CKD anaemia treated?
Optimise iron status
EPO weekly injection
How is renal bone disease managed?
Reduce phosphate and PTH
- phosphate binder
- vitamin D
Describe haemodialysis and the associated risks
3 sessions/week
requires a fistula in lower arm
Risks - infection, endocarditis, stenosis, hypotension, arrhythmia, thrombus, air embolus, steal syndrome, disequilibrium
Describe the two types of peritoneal dialysis
Continuous - drained every few hours
Automated - drained overnight
What immunosuppression is needed after a kidney transplant?
Ciclosporin/tacrolimus
Monoclonal antibody
MMF or sirolimus
What drug is given in acute transplant rejection?
Steroids
Name the three types of rejection of renal transplant
Hyperacute
Acute
Chronic
What will a biopsy of diabetic nephropathy look like?
Kimmelstein Wilson lesions - nodular glomerulosclerosis
What is the most common cause of chronic pyelonephritis?
Vesicle-ureteric reflux usually presents in childhood with recurrent infection
What causes renal artery stenosis?
Atherosclerosis
Fibromuscular dysplasia
How does renal artery stenosis present?
HTN, AKI, flash pulmonary oedema, CKD, renal bruit, different sized kidneys
How do you treat renal artery stenosis?
Statin
ACE inhibitor
Anti-platelet
What is the appearance of fibromuscular dysplasia on angiography?
String bean
How does endothelial or mesangial cell damage present?
Haematuria
How does podocyte damage present?
Proteinuria
Describe nephrotic syndrome
Proteinuria
Hypo-albuminaemia
Oedema
Describe nephritic syndrome
Oliguria
Haematuria - red cell casts
Hypertension
Describe IgA nephropathy
Most common
Haematuria in young males post URTI
HSP and coeliac
IgA and C3 deposits
How do you treat IgA nephropathy?
BP control - ACEi/ARB
Describe minimal change nephropathy
Children with nephrotic syndrome
T cell damage - podocytes
Podocyte fusion
How do you treat minimal change nephropathy ?
Steroids
Describe focal segmental glomuerulosclerosis
Young adults with nephrotic syndrome
Primary
Secondary - HIV, reflux/IgA, heroin, Alports, sickle cell
Sclerosis and complement
Describe membranous nephropathy
Adults with proteinuria and nephrotic
Anti-PlA2
Secondary - infection, malignancy, NSAIDs, systemic disease
Thick BM with sub-epithelial deposits
How is focal segmental glomerulosclerosis treated?
Steroids
Immunosuppression
50% ESRF
How is membranous nephropathy treated?
ACEi/ARB
Immunosuppression - steroids, mab, cyclophosphamide
30% ESRF
Describe rapidly progressive glomerulonephritis
Granular casts AKI
Nephritic syndrome
ANCA or goodpastures/SLE