overdoses

Question 1

amitriptyline overdose

Answer 1

TCA overdose

increases serotonin and noradrenaline by slowing the re-uptake but also blocks histamine, cholinergic and alpha-1-receptors

symptoms- anticholingeric effects. dilated pupils, dry skin, confusion, urinary retention and tachycardia. prolonged QTc internal with wide QRS (can lead to V arrhythmias)

Question 2

cocaine overdose

Answer 2

agitation
restlesness
tachycardia
hypertension

Question 3

sertraline OD

Answer 3

seretonin syndrome
hyper-reflexia
muscle rigidity
tremor

Question 4

morphine OD

Answer 4

respiratory depression

reduction in conscious level

Question 5

diazepam

Answer 5

some sedative effect (reduction in GCS) and respiratory depression
generally has little effect on HR and ECG

Question 6

salicylate overdose (aspirin)

Answer 6

hyperventilation
tinnitus
metabolic acidosis and respiratory alkalosis

tx: urinary alkilinisatoin or harm-dialysis

Question 7

organophosphate poisoning

Answer 7

muscarinic toxicity:
diarrhoea
miosis
bradycardia
bronchorrhea
emesis
hypotension

treatment: IV atropine therapy (blocks the action for he acetylcholine at muscarinic receptors)
* pralidoxime chloride works to reactivate the inhibited acetylcholinesterase.