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overall review Flashcards

1
Q

C5a attracts

A

PMNs, Macrophages

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2
Q

fibrin split products attracts

A

PMNs

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3
Q

acute respiratory syndrome

A

PMNs

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4
Q

acute transplant

A

lymphocytes, Abs, C’

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5
Q

chronic transplant

A

lymphocytes, cytokines

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6
Q

acute and chronic asthma

A

Eos, IgE, Abs

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7
Q

acute glomerulonephritits

A

PMNs, monocytes, Abs, C’

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8
Q

acute septic shock

A

cytokines

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9
Q

acute lung abscess

A

PMNs

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10
Q

chronic arthritits

A

lymphocytes, macrophages, Abs

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11
Q

chronic atherosclerosis

A

Macrophages, lymphocytes

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12
Q

chronic pulmonary fibrosis

A

macrophages and fibroblasts

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13
Q

histamine

A

dilates arterioles, increases permeability

attracts Eos

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14
Q

histamine released by

A

mast cells, basophils, and platelets

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15
Q

stimuli for histamine release

A 
physical injury
neuropeptides
Ab
C3a & C5a
leukocyte histamine releasing proteins
cytokines (IL1,8)
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16
Q

seratonin

A

same as histamine but released from platelets and neuroendocrine cells due to platelet aggregation

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17
Q

sterorids

A

block phospholipases, can’t make AA

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18
Q

thromboxane A2

A

causes platelet aggregation and vasoconstriction

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19
Q

PGI2

A

aka prostacyclin
blocks platelet aggregation
vasodilates

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20
Q

PGD2

A

pain and fever

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21
Q

PGE2

A

pain, fever, vasodilates

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22
Q

PGF2

A

vasodilates

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23
Q

LTB4

A

chemotactic

24
Q

LTC4,D4,E4

A

vasoconstrict, increase permeability, bronchoconstrict

25
NO
vasodilator blocks SM contraction, leukocytes rolling, adhesion and degranulation, platelet aggregation and adhesion, and mast cell activation
26
iNOS
from macrophages and monocytes stimulated by TNF and INFy
27
substance P
wheal formation GI and lungs causes: pain, endocrine secretions, mast cell activation, increased permeability, controls BP
28
C'
C5-9 = MAC C3a, C5a, C4a increase permeability and vasodilate C5a chemotactic, leukocyte activation, and increased lipogenase C3b- opsonin
29
Eosinophils
from BM regulated by IL3,5 and GM-CSF attracted by histamine, eotoxin, LTB4, CCL5, RANTES released major basic protein
30
granulomatous inflammation
TB, leprosy, syphillis, cat scratch disease, sarcoidosis, chrons disease key to recognition is giant cells
31
fever
IL1,6 TNF IFN-y PGE2
32
neutrapenia
aplastic anemia, radiation, cancer therapy, drug sensitivity, TB
33
adherence deficits
hereditary, glucocorticoids, DM, NO, alcohol, hemodialysis
34
movement defects
DM
35
chemotaxis defects
thermal injuries, DM, cancer, sepsis, immunodeficiency,
36
phagocytosis defects
DM, C', Ig deficiencies, neonates, malnutrition, cancer, anemia, sepsis, chediak higashi syndrome
37
ROS defects
chronic granulmatous disease | MPO deficiencies
38
EGF produced by
from platelets, Mo, salivia, uriine, milk, plasma
39
EGF effects
increases and activates keratinocytes, fibroblasts, glial cells, granulation tissue
40
TGF alpha produced by
from Mos, endothelium, keratinocytes, SMCs
41
TGFalpha effects
similar to EGF | increases hepatocytes and epithlium
42
VEGF produced by
many cells
43
VEGF effects
increase vascular perm increase endothelium angiogenesis
44
PDGF produced by
platelets, Mos, endothelium, keratinocytes, SMCs
45
PDGF effects
chemotaxis, activation, mitogenic for PMNs, Mo, fibroblasts, endothelium, and SCM increased production of MMPs, fibronectin, HA increased angiogenesis and wound contraction
46
FGF produced by
from Mo, mast cells, Tcells, endothelium, and fibroblasts
47
FGF effects
chemotactic and mitogenic for fibroblasts and keratinocytes | increases keratinocyte migration, angiogenesis, wound contraction, matrix deposition
48
TGFbeta produced by
from platelets, Tcells, Mos, SCM, endothelium, keratinocytes, fibroblasts
49
TGFbeta effects
chemotactic for PMNS, Mos, lymphocytes, fibroblasts, SMC increase TIMP, angiogenesis, fibroplasia blocks MMPs and keratinocyte migration
50
KGF/ FGF7 produced by
fibroblasts
51
KGF/FGF7 effects
stimulates keratinocyte migration, proliferation, and differentiation
52
TNF produced by
Mos, mast cells, T cells
53
TNF effects
activates Mo, regulates cytokines
54
proteoglycans
regulates ECM structure and perm modulate growth and differentiation maintain cell morphology diffuse location
55
glycoproteins
fibronectin, laminin, vitreonectin link ECM to cells via integrins adhesive on/near cell surface
56
collagens
I- bone, tendons II- cartilage III- laid down in repair, then replaced by I IV- BM

PBD1 (6 decks)

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