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PBD1 > overall review > Flashcards

overall review Flashcards

1
Q

C5a attracts

A

PMNs, Macrophages

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2
Q

fibrin split products attracts

A

PMNs

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3
Q

acute respiratory syndrome

A

PMNs

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4
Q

acute transplant

A

lymphocytes, Abs, C’

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5
Q

chronic transplant

A

lymphocytes, cytokines

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6
Q

acute and chronic asthma

A

Eos, IgE, Abs

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7
Q

acute glomerulonephritits

A

PMNs, monocytes, Abs, C’

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8
Q

acute septic shock

A

cytokines

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9
Q

acute lung abscess

A

PMNs

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10
Q

chronic arthritits

A

lymphocytes, macrophages, Abs

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11
Q

chronic atherosclerosis

A

Macrophages, lymphocytes

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12
Q

chronic pulmonary fibrosis

A

macrophages and fibroblasts

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13
Q

histamine

A

dilates arterioles, increases permeability

attracts Eos

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14
Q

histamine released by

A

mast cells, basophils, and platelets

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15
Q

stimuli for histamine release

A 
physical injury
neuropeptides
Ab
C3a & C5a
leukocyte histamine releasing proteins
cytokines (IL1,8)
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16
Q

seratonin

A

same as histamine but released from platelets and neuroendocrine cells due to platelet aggregation

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17
Q

sterorids

A

block phospholipases, can’t make AA

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18
Q

thromboxane A2

A

causes platelet aggregation and vasoconstriction

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19
Q

PGI2

A

aka prostacyclin
blocks platelet aggregation
vasodilates

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20
Q

PGD2

A

pain and fever

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21
Q

PGE2

A

pain, fever, vasodilates

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22
Q

PGF2

A

vasodilates

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23
Q

LTB4

A

chemotactic

24
Q

LTC4,D4,E4

A

vasoconstrict, increase permeability, bronchoconstrict

25
Q

NO

A

vasodilator
blocks SM contraction, leukocytes rolling, adhesion and degranulation, platelet aggregation and adhesion, and mast cell activation

26
Q

iNOS

A

from macrophages and monocytes stimulated by TNF and INFy

27
Q

substance P

A

wheal formation
GI and lungs
causes: pain, endocrine secretions, mast cell activation, increased permeability, controls BP

28
Q

C’

A

C5-9 = MAC
C3a, C5a, C4a increase permeability and vasodilate
C5a chemotactic, leukocyte activation, and increased lipogenase
C3b- opsonin

29
Q

Eosinophils

A

from BM regulated by IL3,5 and GM-CSF
attracted by histamine, eotoxin, LTB4, CCL5, RANTES
released major basic protein

30
Q

granulomatous inflammation

A

TB, leprosy, syphillis, cat scratch disease, sarcoidosis, chrons disease
key to recognition is giant cells

31
Q

fever

A

IL1,6
TNF
IFN-y
PGE2

32
Q

neutrapenia

A

aplastic anemia, radiation, cancer therapy, drug sensitivity, TB

33
Q

adherence deficits

A

hereditary, glucocorticoids, DM, NO, alcohol, hemodialysis

34
Q

movement defects

A

DM

35
Q

chemotaxis defects

A

thermal injuries, DM, cancer, sepsis, immunodeficiency,

36
Q

phagocytosis defects

A

DM, C’, Ig deficiencies, neonates, malnutrition, cancer, anemia, sepsis, chediak higashi syndrome

37
Q

ROS defects

A

chronic granulmatous disease

MPO deficiencies

38
Q

EGF produced by

A

from platelets, Mo, salivia, uriine, milk, plasma

39
Q

EGF effects

A

increases and activates keratinocytes, fibroblasts, glial cells, granulation tissue

40
Q

TGF alpha produced by

A

from Mos, endothelium, keratinocytes, SMCs

41
Q

TGFalpha effects

A

similar to EGF

increases hepatocytes and epithlium

42
Q

VEGF produced by

A

many cells

43
Q

VEGF effects

A

increase vascular perm
increase endothelium
angiogenesis

44
Q

PDGF produced by

A

platelets, Mos, endothelium, keratinocytes, SMCs

45
Q

PDGF effects

A

chemotaxis, activation, mitogenic for PMNs, Mo, fibroblasts, endothelium, and SCM
increased production of MMPs, fibronectin, HA
increased angiogenesis and wound contraction

46
Q

FGF produced by

A

from Mo, mast cells, Tcells, endothelium, and fibroblasts

47
Q

FGF effects

A

chemotactic and mitogenic for fibroblasts and keratinocytes

increases keratinocyte migration, angiogenesis, wound contraction, matrix deposition

48
Q

TGFbeta produced by

A

from platelets, Tcells, Mos, SCM, endothelium, keratinocytes, fibroblasts

49
Q

TGFbeta effects

A

chemotactic for PMNS, Mos, lymphocytes, fibroblasts, SMC
increase TIMP, angiogenesis, fibroplasia
blocks MMPs and keratinocyte migration

50
Q

KGF/ FGF7 produced by

A

fibroblasts

51
Q

KGF/FGF7 effects

A

stimulates keratinocyte migration, proliferation, and differentiation

52
Q

TNF produced by

A

Mos, mast cells, T cells

53
Q

TNF effects

A

activates Mo, regulates cytokines

54
Q

proteoglycans

A

regulates ECM structure and perm
modulate growth and differentiation
maintain cell morphology
diffuse location

55
Q

glycoproteins

A

fibronectin, laminin, vitreonectin
link ECM to cells via integrins
adhesive
on/near cell surface

56
Q

collagens

A

I- bone, tendons
II- cartilage
III- laid down in repair, then replaced by I
IV- BM

PBD1 (6 decks)

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