Ovarian Cancer

Question 1

Risk

Answer 1

Multiple pregnancies 
Age
HRT
Smoking
High BMI

Question 2

Genetics

Answer 2

5% clearly hereditary
BRCA1/ BRCA2
Lynch families

Question 3

Pathology

Answer 3

Epithelial

Question 4

Common forms of epithelial ovarian cancers

Answer 4

Serous

Endometrioid

Question 5

CA125

Answer 5

advanced cancer: elevated

Not specific for ovarian cancer

Question 6

Presentation

Answer 6

Abdominal discomfort, swelling
Bloating
Change in bowel habit
GI and urinary symptoms

Question 7

Stage IV

Answer 7

Distant metastases

Question 8

Stage III

Answer 8

Tumour w/ peritoneal implantation outwith the pelvis or involved small bowel, retroperitoneal or inguinal nodes

Question 9

Stage II

Answer 9

Tumour w/ pelvic extension only

Question 10

Stage Ia

Answer 10

Tumour confined to one ovary

Question 11

Stage Ib

Answer 11

Tumour confined to both ovaries

Question 12

Stage Ic

Answer 12

Tumour stage I but with capsule ruptured or malignant ascites

Question 13

Management of epithelial ovarian cancer

Answer 13

Surgery

• midline incision
• total abd. hysterectomy
• bilateral salpingo-oophorectomy
• omentectomy
• multiple peritoneal biopsies and washings

Question 14

Which lymph nodes are sampling?

Answer 14

Para-aortic and pelvic regions

Question 15

1st Line chemotherapy

Answer 15

Platinum and taxane