Ovarian Cancer Flashcards
What is the lifetime risk of ovarian cancer with BRCA1 mutation?
40%
What is the lifetime risk of ovarian cancer with BRCA2 mutation?
20%
Stage 1 ovarian cancer
Limited to ovary or fallopian tube
1A - one ovary
1B - both ovaries
1C - one or both ovaries with surgical spill or surface involvement
Stage 2 ovarian cancer
Extension in the pelvis
2A - implants on the gynecologic organs
2B - implants on pelvic tissues
Stage 3 ovarian cancer
Outside of the pelvis or involving nodes
Stage 4 ovarian cancer
4A - positive pleural cytology
4B - transmural intestinal involvement, spread to liver or spleen, extra-abdominal organs
What is the staging procedure for ovarian cancer?
Pelvic washings, BSO, hysterectomy, peritoneal biopsies, pelvic and para-aortic lymph node dissection, omentectomy
What are typical immunohistochemical stains for serous ovarian tumors?
CK7, CA125, PAX8, WT1
What is the chemotherapy treatment for most germ cell tumors?
Bleomycin, etoposide, cisplatin
Treatment of stage IA grade 1 immature teratoma
Observation
What factors necessitate a gyn onc referral for a premenopausal female with a pelvic mass?
CA-125 > 200
Ascites
Family hx of breast or ovarian cancer in a first-degree relative
What factors necessitate a gyn onc referral for a postmenopausal female with a pelvic mass?
CA-125 > 35
Ascites
Nodular or fixed pelvic mass
Fam hx of breast or ovarian cancer in a first-degree relative
What is the rate of progression of complex endometrial hyperplasia with atypia to endometrial cancer?
29%
Workup of granulosa cell tumors should include what procedure?
Endometrial sampling
What is the antibiotic regimen for outpatient treatment of febrile neutropenia?
Ciprofloxacin and augmentin
