ovarian cancer Flashcards
1
Q
RFs
A
genetic:
HNPCC (Lynch type II)
BRCA 1 and 2
FHx
2
Q
very high risk women management?
A
prophylactic oophorectomy
3
Q
pc stage
A
most Stage 3 or 4 - advanced = high grade carcinomas
4
Q
pc symptoms
A
vague:
GI changes - constipation, bloating, loss of appetite, abdominal mass (pressure symptoms),
5
Q
diagnostic investigations
A
u x m x CA 125
u/s
menopausal?
Level of CA 125
6
Q
staging
A
- ovaries 85% cure rate
- pelvic extension 47%
- nodes 15%
- mets 10%
7
Q
mets where?
A
spleen, liver
8
Q
tx
A
laparotomy - TAH + BSO (debulking)
adjuvant/neo chemo: platinum or taxane with surgery
palliation: tamoxifen
