Ovarian and Bladder Cancer

Question 1

What rank is ovary cancer death toll?

Answer 1

5th: very common, late presentation

Question 2

What is marker for ovarian cancer?

Answer 2

CA-125: staging and Tx effectiveness

Question 3

What is typical ovary tx?

Answer 3

Intraperitoneal Cisplatin: stage I

Add more chemo as stage increases

Question 4

What are most bladder carcinomas?

Answer 4

Transitional cell, superficial

Question 5

Presentation of almost all bladder cancers?

Answer 5

Hematuria

Question 6

How is chemo used in bladder?

Answer 6

Put intravesicularly

Question 7

Carboplatin/Cisplatin MOA, AE?

Answer 7

MOA; DNA crosslinks

AE: nephro, ototoxic, HS reaction

Question 8

Cyclophosphomide MOA/AE?

Answer 8

MOA: Prodrug alkylator

AE: hemorrhagic cystitis (MESNA), anemia, amenorhea, infertility, 2* neoplasm, pulmonary fibrosis

Question 9

Doxorubicin MOA/AE?

Answer 9

MOA:

1. intercalator
2. ROS free radical
3. topo2 inhibitor

AE: 
   Dose limiting Cardio (Dexrazoxane prevents)
   Myelosuppression
   CHF
   LIver
   2* neoplasm
   extransational necrosis

Question 10

Paclitaxel MOA/AE?

Answer 10

MOA:
microtubule STABILIZER

AE:
    HS
    Myelosuppresion
    peripheral neuropathy
    arthralgia, myalgia

Question 11

BCG: Bacillys Calmette Guerin MOA, AE?

Answer 11

MOA:
used >1 year
activates APC in urothelium, sensitizes them
effect for months

AE:
none!

Question 12

Mitomycin C MOA, AE?

Answer 12

MOA:
alkylator: bi and mono functional

AE: 
   LUNG: pneumonitis
   pancytopenia
   hemorrhagic cystitis
   PISS: dermatitis on palms

Question 13

Pee on hands, get dermatitis, what drug?

Answer 13

Mitomycin (Mighty piss!)

Question 14

Thiotepa MOA, AE?

Answer 14

MOA:

1. 3 aziridine groups get hydrolyzed: alkylate DNA
2. Remaining drug intrastrand cross links

AE:
   Pancytopenia
   Dysuria
   Urine retention
   Hemorrhagic cystitis
   Renal dysfunction

Question 15

What drug do you want to monitor ejection fraction?

Answer 15

Doxorubicin